EVIDENCE FOR LARGE SCALE CHROMOSOMAL VARIATIONS IN NEURONAL CELLS OF THE FETAL HUMAN BRAIN
Yurov YB1,*, Vostrikov VS1, Monakhov VV1, Iourov IY1, Vorsanova SG2,*
*Corresponding Author: Professor Yuri B. Yurov and Professor Svetlana G. Vorsanova, Cytogenetic Labora¬tory; National Center of Mental Health, Russian Academy of Medical Sciences, Zagorodnoe shosse 2, Moscow 113 152, Russia; Tel.: +7-095-952-89-90; Fax: 7-095-952-89-40; E-mail: y_yurov@hotmail.com; y_yurov@ yahoo.com
page: 95

REFERENCES

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3. Voullaire L, Slater H, Williamson R, Wilton L. Chromosome analysis of blastomeres from human embryos by using comparative genomic hybridization. Hum Genet 2000; 106(2): 210-217.

4. Harrison RH, Kuo H, Scriven PN, Handyside AH, Ogilivie CM. Lack of cell cycle checkpoints in human cleavage stage embryos revealed by a clonal pattern of chromosomal mosaicism analysed by sequential multi­colour FISH. Zygote 2000; 8(3): 217-224.

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6. Yurov YB, Vostrikov VM, Vorsanova SG, Mona­khov VV. Large-scale genomic variations in developing neuronal cells of the brain. Human Genome Meeting, Cancun, Mexico (Abstract) 2003; 113.

7. Victorov IV, Lyjin AA, Aleksandrova OP. A modi­fied roller method for organotypic brain cultures: free-floating slices of postnatal rat hippocampus. Brain Res Protocols 2001; 7(1): 30-37.

8. Yurov YB, Soloviev IV, Vorsanova SG, Marcais B, Roizes G, Lewis R. High resolution fluorescence in situ hybridization using cyanine and fluorescin dyes: ultra-rapid chromosome detection by directly fluorescently labeled alphoid DNA probes. Hum Genet 1996; 97(3): 390-398.

9. Soloviev IV, Yurov YB, Ioannou I, Georghiou A, Hadjimarcou M, Patsalis PC, Roizes G, Sharonin VO, Kravets VS, Vorsanova SG. Identification and molecular-cytogenetic characterization of large subsets of human plasmid, cosmids, PAC and YAC clones: the search of DNA probes for pre- and postnatal diagnosis. Cs Pediatr 1997; 52(7): 529-538.

10. Soloviev IV, Yurov YB, Vorsanova SG, Marcais B, Rogaev EI, Kapanadze BI, Brodiansky VM, Yan­­kovsky NK, Roizes G. Fluorescent in situ hybridization analysis of a-satellite DNA in cosmid libraries specific for human chromosomes 13, 21 and 22. Rus J Genet 1998; 34(11): 1247-1255.

11. Soloviev IV, Yurov YB, Vorsanova SG, Malet P. Microwave activation of fluorescence in situ hybridiza­tion: a novel method for rapid chromosome detection and analysis. Focus 1994; 16(4): 115-116.

12. Yang Y, Geldmacher DS, Herrup K. DNA Repli­cation precedes neuronal cell death in Alzheimer’s dis­ease. J Neurosci 2001; 21(8): 2661-2668.

13. Yurov YB, Vostrikov VM, Vorsanova SG, Mona­khov VV, Iourov IY. Multicolor fluorescent in situ hybrid­ization on post mortem brain in schizophrenia as an ap­proach for identification of low-level chromosomal aneu­ploidy in neuropsychiatric diseases. Brain Dev 2001; 23(1): 186-190.




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