UNUSUAL MANIFESTATION OF EXTRAOSSEOUS
EWING SARCOMA: REPORT OF 3 CASES
Ioannidou M.1,*, Tsotridou E.1, Samoladas E.2, Tragiannidis A.1, Kouskouras K.3,
Sfougaris D.4, Spyridakis I.5, Foroulis C.6, Galli-Tsinopoulou A.1, Hatzipantelis E.1
*Corresponding Author: MD Maria Ioannidou, St Kiriakidi 1, Children’s and Adolescent’s Hematology-
Oncology Unit of 2nd Department of Pediatrics, AUTh, AHEPA University General Hospital,
Thessaloniki, Greece. Zip code: 54621. Tel.: 00306942067923. E-mail: ioannidou@auth.gr
page: 77
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CASE REPORT 3
A 12 year-old girl was referred to our Unit due to a
painless growing mass located on her right forearm, which
was initially detected 3 months ago. Physical examination
revealed a palpable mass of 12x5mm on the aspect of the
right proximal forearm, with no signs of inflammation,
and no other clinical findings. She underwent hematology/
biochemistry tests and chest X-Ray, which were normal.
An ultrasound was performed, revealing a soft-tissue mass
in the subcutaneous tissue of the flexor surface of the right
forearm near the elbow joint with increased vascularization.
A small nodule, 6mm in diameter, in the right lower
lobe was detected on the chest CT . The patient underwent
resection of the mass which was completely removed.
Histopathological examination showed a tumor with a
nodular growth pattern.
The monomorphic infiltrate consisted of small tumor
cells with scanty cytoplasm and round nuclei. Immunohistochemistry
revealed tumor cells with positivity for vimentin,
CD99 and bcl2. Molecular biological examination
was also performed but no transcripts t(11;22), t(21;22),
t(X;18) were detected. She underwent chemotherapy according
to EURO-E.W.I.N.G.99 chemotherapy protocol.
So far, 18 months after the end of chemotherapy, there is
no evidence of recurrence or metastases and she has an
excellent quality of life.
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