UNUSUAL MANIFESTATION OF EXTRAOSSEOUS
EWING SARCOMA: REPORT OF 3 CASES
Ioannidou M.1,*, Tsotridou E.1, Samoladas E.2, Tragiannidis A.1, Kouskouras K.3,
Sfougaris D.4, Spyridakis I.5, Foroulis C.6, Galli-Tsinopoulou A.1, Hatzipantelis E.1
*Corresponding Author: MD Maria Ioannidou, St Kiriakidi 1, Children’s and Adolescent’s Hematology-
Oncology Unit of 2nd Department of Pediatrics, AUTh, AHEPA University General Hospital,
Thessaloniki, Greece. Zip code: 54621. Tel.: 00306942067923. E-mail: ioannidou@auth.gr
page: 77
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CASE REPORT 2
A 14-year–old girl was referred to our Unit following
complete resection of a palpable abdominal mass. One
month prior to surgery, the patient observed a swelling in
the right hypochondrium. There was no history of pain,
fever, weight loss, fatigue, excessive sweating or gastrointestinal
complaints. An abdominal ultrasound revealed a
hypoechoic, round lesion, approximately 30mm in diameter,
without internal vasculature. There was no attachment
to the diaphragm or chest wall. Initial MRI imaging (Figure
2) and staging revealed no skeletal involvement or metastatic
disease. Complete resection of the mass was performed
and histopathological examination demonstrated
small, round tumor cells with oval nucleus, surrounded by
eosinophilic cytoplasm. Immunohistochemistry revealed
positivity for vimentin, CD99 and bcl2. Molecular biological
examination was also performed but no transcripts t(11;22), t(21;22) or t(X;18) were detected. After radical
surgical excision the patient underwent adjuvant chemotherapy
according to EURO-E.W.I.N.G.99 protocol. To
date, no recurrence has been observed, 4 years after the
end of chemotherapy.
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