EVALUATION OF METHYLATION PROFILES OF AN EPIDERMAL GROWTH FACTOR RECEPTOR GENE IN A HEAD AND NECK SQUAMOUS CELL CARCINOMA PATIENT GROUP
Mutlu M, Mutlu P, Azarkan S, Bayır O, Ocal B, Saylam G, Korkmaz MH
*Corresponding Author: Associate Professor Murad Mutlu, M.D., Department of Otorhinolaringology, Health Sciences University, Ministry of Health, Dışkapı Yildirim Beyazit Training and Research Hopsital, Sehit Ömer Halisdemir Street, No. 20, 06110, Dışkapı, Ankara, Turkey. Tel.: +90-312-516-2000. Fax: +90-312-318-6690. E-mail: muradmutlu78@yahoo.com
page: 65

REFERENCES

1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics. CA Cancer J Clin. 2005; 55(2): 74-108. 2. Boonkitticharoen V, Kulapaditharom B, Leopairut J, Kraiphibul P, Larbcharoensub N, Cheewaruangroj W, et al. Vascular endothelial growth factor a and proliferation marker in prediction of lymph node metastasis in oral and pharyngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2008; 134(12): 1305-1311. 3. Eleftheriadou A, Chalastras T, Ferekidou E, Yio-takis I, Kyriou L, Tzagarakis M, et al. Association between squamous cell carcinoma of the head and neck and serum folate and homocysteine. Anticancer Res. 2006; 26(3B): 2345-2348. 4. Lo AK, Lo KW, Tsao SW, Wong HL, Hui JW, To KF, et al. Epstein-Barr virus infection alters cellular signal cascades in human nasopharyngeal epithelial cells. Neoplasia. 2006; 8(3): 173-180. 5. Hennessey PT, Westra WH, Califano JA. Human papillomavirus and head and neck squamous cell carcinoma: recent evidence and clinical implications. J Dent Res. 2009; 88(4): 300-306. 6. Weber BL. Cancer genomics. Cancer Cell. 2002; 1(1): 37-47. 7. Ha PK, Chang SS, Glazer CA, Califano JA, Sidransky D. Molecular techniques and genetic alterations in head and neck cancer. Oral Oncol. 2009; 45(4-5): 335-339. 8. Cassidy LD, Venkitaraman AR. Genome instability mechanisms and the structure of cancer genomes. Curr Opin Genet Dev. 2012; 22(1): 10-13. 9. Viet CT, Schmidt BL. Understanding oral cancer in the genome era. Head Neck. 2010; 32(9): 1246-1268. 10. Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, et al. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science. 2011; 333(6046): 1154-1157. 11. Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, et al. The mutational landscape of head and neck squamous cell carcinoma. Science. 2011; 333(6046): 1157-1160. 12. Chung CH, Ely K, McGavran L, Varella-Garcia M, Parker J, Parker N, et al. Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas. J Clin Oncol. 2006; 24(25): 4170-4176. 13. Hynes NE, Lane HA. ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer. 2005; 5(5): 341-354. 14. Leemans CR, Braakhuis BJ, Brakenhoff RH. The molecular biology of head and neck cancer. Nat Rev Cancer. 2010; 11(1): 9-22. 15. Kanai Y, Hirohashi S. Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from precancerous to malignant state. Carcinogenesis. 2007; 28(12): 2434-2442. 16. Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet. 2002; 3(6): 415-428. 17. Ushijima T. Detection and interpretation of altered methylation patterns in cancer cells. Nat Rev Cancer. 2005; 5(3): 223-231. 18. Baylin SB, Ohm JE. Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction? Nat Rev Cancer. 2006; 6(2): 107-116. 19. Lee S, Kim WH, Jung HY, Yang MH, Kang GH. Aberrant CpG island methylation of multiple genes in intrahepatic cholangiocarcinoma. Am J Pathol. 2002; 161(3): 1015-1022. 20. Hasegawa M, Nelson HH, Peters E, Ringstrom E, Posner M, Kelsey KT. Patterns of gene promoter methylation in squamous cell cancer of the head and neck. Oncogene. 2002; 21(27): 4231-4236. 21. Loyo M, Brait M, Kim MS, Ostrow KL, Jie CC, Chuang AY, et al. A survey of methylated candidate tumor suppressor genes in nasopharyngeal carcinoma. Int J Cancer. 2011; 128(6): 1393-1403. 22. Dikshit RP, Gillio-Tos A, Brennan P, De Marco L, Fiano V, Martinez-Peñuela JM, et al. Hypermethylation, risk factors, clinical characteristics, and survival in 235 patients with laryngeal and hypopharyngeal cancers. Cancer. 2007; 110(8): 1745-1751. 23. Poage GM, Christensen BC, Houseman EA, Mc- Clean MD, Wiencke JK, Posner MR, et al. Genetic and epigenetic somatic alterations in head and neck squamous cell carcinomas are globally coordinated but not locally targeted. PLoS One. 2010; 5(3): e9651. 24. Sanchez-Cespedes M, Esteller M, Wu L, Yoo GH, Koch WM, Jen J, et al. Gene promoter hypermethylation in tumors and serum of head and neck cancer patients. Cancer Res. 2000; 60(4): 892-895. 25. Ogi K, Toyota M, Ohe-Toyota M, Tanaka N, Noguchi M, Sonoda T, et al. Aberrant methylation of multiple genes and clinicopathological features in oral squamous cell carcinoma. Clin Cancer Res. 2002; 8(10): 3164-3171. 26. Saloura V, Vougiouklakis T, Zewde M, Deng X, Kiyotani K, Park J-H, et al. WHSC1L1-mediated EGFR mono-methylation enhances the cytoplasmic and nuclear oncogenic activity of EGFR in head and neck cancer. Sci Rep. 2017; 7: 40664. 27. Liao H-W, Hsu J-M, Xia W, Wang H-L, Wang Y-N, Chang W-C, et al. PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response. J Clin Invest. 2015; 125(12): 4529-4543. 28. Stein RA. Epigenetics-the link between infectious diseases and cancer. JAMA. 2011; 305(14): 1484- 1485. 29. Nagothu KK, Rishi AK, Jaszewski R, Kucuk O, Majumdar APN. Folic acid- mediated inhibition of serum-induced activation of EGFR promoter in colon cancer cells. Am J Physiol Gastrointest Liver Physiol. 2004; 287(3): G541-G546. 30. Langevin SM, Koestler DC, Christensen BC, Butler RA, Wiencke JK, Nelson HH, et al. Peripheral blood DNA methylation profiles are indicative of head and neck squamous cell carcinoma: An epigenome-wide association study. Epigenetics. 2012; 7(3): 291-299. 31. Rosas SL, Koch W, Costa Carvalho MG, Wu L, Califano J, Westra W, et al. Promoter hypermethylation patterns of p16 O-6-methylguanine-DNA methyltransferase, and death-associated protein kinase in tumors and saliva of head and neck cancer patients. Cancer Res. 2001; 61(3): 939-942. 32. Nagase H, Ghosh S. Epigenetics: differential DNA methylation in mammalian somatic tissues. FEBS J. 2008; 275(8): 1617-1623. 33. Costello JF, Frushwald MC, Smiraglia DJ, Rush LJ, Robertson GP, Gao X, et al. Aberrant CpG-island methylation has non-random and tumor-type-specific patterns. Nat Genet. 2000; 24(2): 132-138. 34. Goldenberg D, Harden S, Masayesva BG, Ha P, Benoit N, Westra WH, et al. Intraoperative molecular margin analysis in head and neck cancer. Arch Otolaryngol Head Neck Surg. 2004; 130(1): 39-44. 35. Zvonko M, Supić G, Branković-Magić M, Jović N. DNA methylation in the pathogenesis of head and neck cancer. In: Dricu A, editor. Methylation – From DNA, RNA and Histones to Diseases and Treatment. London, UK: InTech. 2012: 185-216. doi: 10.5772/51169. 36. Arantes LMRB, de Carvalho AC, Melendez ME, Carvalho AL, Goloni-Bertollo EM. Methylation as a biomarker for head and neck cancer. Oral Oncol. 2014; 50(6): 587-592. 37. Freedman L. Quantitative science methods for biomarker validation in chemoprevention trials. Cancer Biomark. 2007; 3(3): 135-140. 38. Maiti GP, Mondal P, Mukherjee N, Ghosh A, Ghosh S, Dey S, et al. Overexpression of EGFR in head and neck squamous cell carcinoma is associated with inactivation of SH3GL2 and CDC25A genes. PLoS One. 2013; 8(5): e63440. 39. de Vos L, Gevensleben H, Schröck A, Franzen A, Kristiansen G, Bootz F, et al. Comparison of quantification algorithms for circulating cell-free DNA methylation biomarkers in blood plasma from cancer patients. Clin Epigenet. 2017; 9: 125. 40. Widschwendter M, Apostolidou S, Raum E, Rothenbacher D, Fiegl H, Menon U, et al. Epigenotyping in peripheral blood cell DNA and breast cancer risk: A proof of principle study. PLoS One. 2008; 3(7): e2656. 41. Pedersen KS, Bamlet WR, Oberg AL, de Andrade M, Matsumoto ME, Tang H, et al. Leukocyte DNA meth-ylation signature differentiates pancreatic cancer patients from healthy controls. PLoS One. 2011; 6(3): 18223. 42. Marsit CJ, Koestler DC, Christensen BC, Karagas MR, Houseman EA, Kelsey KT. DNA methylation array analysis identifies profiles of blood-derived DNA methylation associated with bladder cancer. J Clin Oncol. 2011; 29(9): 1133-1139. 43. Pulling LC, Divine KK, Klinge DM, Gilliland FD, Kang T, Schwartz AG, et al. Promoter hypermethylation of the O6-methylguanine-DNA methyltransferase gene: more common in lung adenocarcinomas from never-smokers than smokers and associated with tumor progression. Cancer Res. 2003; 63(16): 4842-4848. 44. Liu Y, Lan Q, Siegfried JM, Luketich JD, Keohavong P. Aberrant promoter methylation of p16 and MGMT genes in lung tumors from smoking and never-smoking lung cancer patients. Neoplasia. 2006; 8(1): 46-51. 45. Issa JP, Ottaviano YL, Celano P, Hamilton SR, Davidson NE, Baylin SB. Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet. 1994; 7(4): 536-540. 46. Montero AJ, Diaz-Montero CM, Mao L, Youssef EM, Estecio M, Shen L, et al. Epigenetic inactivation of EGFR by CpG island hypermethylation in cancer. Cancer Biol Ther. 2006; 5(11): 1494-1501.



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