EVALUATION OF METHYLATION PROFILES OF AN
EPIDERMAL GROWTH FACTOR RECEPTOR GENE
IN A HEAD AND NECK SQUAMOUS CELL
CARCINOMA PATIENT GROUP
Mutlu M, Mutlu P, Azarkan S, Bayır O, Ocal B, Saylam G, Korkmaz MH
*Corresponding Author: Associate Professor Murad Mutlu, M.D., Department of Otorhinolaringology,
Health Sciences University, Ministry of Health, Dışkapı Yildirim Beyazit Training and Research Hopsital,
Sehit Ömer Halisdemir Street, No. 20, 06110, Dışkapı, Ankara, Turkey. Tel.: +90-312-516-2000.
Fax: +90-312-318-6690. E-mail: muradmutlu78@yahoo.com
page: 65
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Abstract
Upregulation of the epidermal growth factor receptor
(EGFR) gene has shown an important impact on the
development of head and neck cancers due to its important
regulation role on multiple cell signaling pathways. The
aim of this study was to investigate the methylation pattern
of the promoter region of the EGFR gene between head
and neck squamous cell carcinoma (HNSCC) patients and
a control group. Forty-seven unrelated HNSCC patients,
clinically diagnosed at the Department of Otorhinolaryngology,
Dışkapı Yıldırım Beyazıt Training and Research
Hospital, Ankara, Turkey, and 48 unrelated healthy volunteers
from different geographic regions of Turkey, were
included in this study. Methylation status of the promoter
region of the EGFR gene was detected by methylationspecific-
polymerase chain reaction (MS-PCR). The correlation
between EGFR gene promoter methylation profiles
and clinical characteristics were examined using the χ2 test.
Methylation was observed in 79.0% of HNSCC patients,
whereas this ratio was 90.0% in healthy individuals. The
results show that promoter region methylation of the EGFR
gene was not associated with HNSCC development in the
studied Turkish patient group. In addition, the methylation
status of the EGFR gene promoter was not found to be
related to age, gender or tumor stage.
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