Balkan Journal of Medical Genetics

ANALYSIS OF THE PPARD GENE EXPRESSION LEVEL CHANGES IN FOOTBALL PLAYERS IN RESPONSE TO THE TRAINING CYCLE
Domańska-Senderowska D, Snochowska A, Szmigielska P, Jastrzębski Z, Jegier A, Kiszałkiewicz J, Dróbka K, Jastrzębska J, Pastuszak-Lewandoska D, Cięszczyk P, Maciejewska-Skrendo A, Zmijewski P, Brzeziańska-Lasota E
*Corresponding Author: Piotr Zmijewski, Ph.D., Faculty of Medicine, University of Information Technology and Management in Rzeszow, Rzeszow, Poland. Tel: +48-22-384-08-12. Fax: +48-22-835-09-77. E-mail: zmijewski@op.pl
page: 19

RESULTS

Relative Expression Levels of the PPARD Gene. The median relative expression levels (RQ values) 0.02 in T1 (Q1 = 0.009, Q3 = 0.073) and 0.75 (Q1 = 0.061, Q3 = 5.065) in T2. Significant differences in RQ values were found between T1 and T2 (p = 0.001; Wilcoxon signed rank test), with higher gene expression level in T2 (Figure 1). Analysis of Lipid Profile Parameters Before and After Training. The median values (mmol/L) and interquartile range (IQR) obtained in the quantitative measurements of the parameters of the lipid profile are presented in Table 1. We did not observe any statistically significant differences between the median values of total cholesterol (p = 0.695), HDL (p = 0.658), LDL (p = 0.778) and the TGs concentration (p = 0.235) (Wilcoxon signed rank test) before and after training. Analysis of Absolute FAT (kg) and Relative FAT (%) Parameters Before and After Training. Significant differences were found between the median FAT value [absolute FAT (kg), p = 0.006; relative FAT (%), p = 0.009] before and after training, with lower mean values of FAT (kg) and FAT (%) observed in T2 (Figures 2 and 3). Analysis of the Reciprocal Relationship Between the Expression of the PPARD and Absolute FAT (kg), Relative FAT (%) and Lipid Profile Parameters Before and After Training. Finally, we assessed the reciprocal relationship between the expression level of PPARD gene (median RQ values) and the other examined parameters. The results are presented in Table 2. Significant negative correlation was found between the expression level of PPARD gene and the absolute FAT (kg) value after training (rho = –0.46, p = 0.031) (Figure 4).

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