ANALYSIS OF THE PPARD GENE EXPRESSION
LEVEL CHANGES IN FOOTBALL PLAYERS
IN RESPONSE TO THE TRAINING CYCLE
Domańska-Senderowska D, Snochowska A, Szmigielska P, Jastrzębski Z, Jegier A,
Kiszałkiewicz J, Dróbka K, Jastrzębska J, Pastuszak-Lewandoska D, Cięszczyk P,
Maciejewska-Skrendo A, Zmijewski P, Brzeziańska-Lasota E
*Corresponding Author: Piotr Zmijewski, Ph.D., Faculty of Medicine, University of Information Technology and Management
in Rzeszow, Rzeszow, Poland. Tel: +48-22-384-08-12. Fax: +48-22-835-09-77. E-mail: zmijewski@op.pl
page: 19
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Abstract
The PPARD gene codes protein that belongs to the
peroxisome proliferator-activated receptor (PPAR) family
engaged in a variety of biological processes, including
lipid metabolism in muscle cells. In this study, we assess
the relationship between PPARD gene expression lipid
metabolism parameters and the variation of the PPARD
gene expression before (T1) and after 12 hours of training
(T2) sessions in a group of football players. Peripheral
blood lymphocytes were obtained from 22 football players
(17.5±0.7 years, 178±0.7 cm, 68.05±9.18 kg). The PPARD
gene expression, analyzed by quantitative polymerase
chain reaction (qPCR), was significantly higher after T2
(p = 0.0006). Moreover, at the end of the training cycle,
there was a significant decrease in relative fat tissue (FAT)
(%) (p = 0.01) and absolute FAT (kg) (p = 0.01). A negative
correlation was observed between absolute FAT (kg) and
PPARD gene expression level in T2 (p = 0.03). The levels
of cholesterol and triglyceride (TG) fractions were not
significantly different (p >0.05) before and after training.
No significant relationship between PPARD expression and
cholesterol or TG levels was found. We found that physical
training affects PPARD expression. Moreover, the negative
correlation between PPARD expression and absolute FAT
(kg) level may be indicative of the contribution of PPARD
in metabolic adaptation to increased lipid uptake that can
be used to control the body composition of athletes.
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