ASSOCIATION BETWEEN INHERITED THROMBOPHILIA
IN PREGNANCY AND MICRONUCLEUS FREQUENCY
IN PERIPHERAL BLOOD LYMPHOCYTES
Šošić GM1,*, Jović N2,5, Rakić B3, Dimitrijević A2,4, Varjačić M2,5
*Corresponding Author: Gordana M. Šošić, B.Sc., Department of Cytogenetic Diagnosis, Obstetrics and Gynecology
Clinic, Clinical Center “Kragujevac,” 30 Zmaj Jovina Street, 3400 Kragujevac, Serbia. Tel: +381-63-835-66-24.
Fax: +381-34-37-00-73. Email: gordana.sosic.2011.02@gmail.com
page: 11
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CONCLUSIONS
It can be concluded that the frequency of micronuclei
>4MN/1000BN depends on the presence of thrombophilia,
previous miscarriages, the number of miscarriages and the
number of pregnancies. The presence of thrombophilia in
pregnancy in the study group is the most important predictor variable of increased MN frequency. Based on the
current knowledge, we hypothesize that the DNA damage,
measured by the increase in frequency of MN, probably
occurs as a result of oxidative stress initiated by prothrombotic
condition in the mother’s blood.
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