ASSOCIATION BETWEEN INHERITED THROMBOPHILIA
IN PREGNANCY AND MICRONUCLEUS FREQUENCY
IN PERIPHERAL BLOOD LYMPHOCYTES
Šošić GM1,*, Jović N2,5, Rakić B3, Dimitrijević A2,4, Varjačić M2,5
*Corresponding Author: Gordana M. Šošić, B.Sc., Department of Cytogenetic Diagnosis, Obstetrics and Gynecology
Clinic, Clinical Center “Kragujevac,” 30 Zmaj Jovina Street, 3400 Kragujevac, Serbia. Tel: +381-63-835-66-24.
Fax: +381-34-37-00-73. Email: gordana.sosic.2011.02@gmail.com
page: 11
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Abstract
The aim of this study was to determine possible predictors
of an increased frequency of micronucleus (MN)
and the impact of thrombophilia on the chromosomal instability
in peripheral blood lymphocytes (PBL) of pregnant
women in their first trimester. This study was designed
as a case-control study on 74 pregnant women. It was
performed in the gestational age of 11 to 14 weeks, when
blood samples were collected and incubated for 72 hours.
The individual MN frequency in PBL was measured by
cytokinesis-block micronucleus (CBMN) assay. Women
were grouped in control group [≤4 MN/1000 binucleated
(BN) cells] and case group (>4 MN/1000 BN cells). Potential
mutagenic effects of exogenous/endogenous factors
in pregnant women were analyzed. By analyzing the given
results, it can be concluded that pregnant women with
thrombophilia have 26.69-times more chance of having a
frequency of >4 MN/1000 BN than pregnant women with
no thrombophilia. Our research was primarily aimed at
showing that the presence of thrombophilia was a statistically
important predictor of an increased MN frequency in
pregnant women and it can predict about one-third of the
total variance in MN frequency in the studied population.
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