THE ROLE OF RNA METABOLISM
IN NEUROLOGICAL DISEASES
Alaqeel AM1,2,*, Abou Al-Shaar H3, Shariff RK3, Albakr A2
*Corresponding Author: Ahmed M. Alaqeel, M.D., Department of Neurosurgery, University of Calgary,
1403 29th Street NW, Calgary, Alberta T2N 2T9, Canada. Tel: +403-970-9117. Fax: +403-270-7878. E-mail:
ahmedalaqeel@hotmail.com
page: 5
|
|
CONCLUSIONS
RNA has an extremely important role in various
functions of the body. It has made a significant
contribution toward the normal function of the neural
system. Disrupted functions of RNAs and RNPs are a
source of numerous maladies, including neurodegenerative
diseases. Various ways have been proposed
by which RNA and related proteins can lead to these
disorders. The intricate process of alternative splicing
provides incredible advantages for generating transcriptome
and proteome diversity. It is also responsible
for the risk of malfunction. It is essential that
eliminating or redirecting the splicing of pre-mRNA
results in an effective restoration of the activity and
reduction of RNA toxicity. This clearly shows that
these RNAs have a greater role in these degenerative
diseases than what was thought before. Further studies
will reveal more complex details, which will result
in a better understanding of the treatment modalities
that can be adopted. There is a need for a larger
investment of resources in this area to understand
the mysterious domain of these neurodegenerative
diseases. It has truly left the medical world striving
to unravel the deep secrets behind the molecular and
genetic levels in them.
Declaration of Interest. This study was funded
by the College of Medicine Research Center, Deanship
of Scientific Research, King Saud University,
Riyadh, Saudi Arabia. The authors have no personal
financial or institutional interest in any of the drugs,
materials, or devices described in this article. The
authors have read and approved the final version of
the submitted article. The authors report no conflicts
of interest. The authors alone are responsible for the
content and writing of this article.
|
|
|
|
 |
Number 27
VOL. 27 (2), 2024 |
Number 27
VOL. 27 (1), 2024 |
Number 26
Number 26 VOL. 26(2), 2023 All in one |
Number 26
VOL. 26(2), 2023 |
Number 26
VOL. 26, 2023 Supplement |
Number 26
VOL. 26(1), 2023 |
Number 25
VOL. 25(2), 2022 |
Number 25
VOL. 25 (1), 2022 |
Number 24
VOL. 24(2), 2021 |
Number 24
VOL. 24(1), 2021 |
Number 23
VOL. 23(2), 2020 |
Number 22
VOL. 22(2), 2019 |
Number 22
VOL. 22(1), 2019 |
Number 22
VOL. 22, 2019 Supplement |
Number 21
VOL. 21(2), 2018 |
Number 21
VOL. 21 (1), 2018 |
Number 21
VOL. 21, 2018 Supplement |
Number 20
VOL. 20 (2), 2017 |
Number 20
VOL. 20 (1), 2017 |
Number 19
VOL. 19 (2), 2016 |
Number 19
VOL. 19 (1), 2016 |
Number 18
VOL. 18 (2), 2015 |
Number 18
VOL. 18 (1), 2015 |
Number 17
VOL. 17 (2), 2014 |
Number 17
VOL. 17 (1), 2014 |
Number 16
VOL. 16 (2), 2013 |
Number 16
VOL. 16 (1), 2013 |
Number 15
VOL. 15 (2), 2012 |
Number 15
VOL. 15, 2012 Supplement |
Number 15
Vol. 15 (1), 2012 |
Number 14
14 - Vol. 14 (2), 2011 |
Number 14
The 9th Balkan Congress of Medical Genetics |
Number 14
14 - Vol. 14 (1), 2011 |
Number 13
Vol. 13 (2), 2010 |
Number 13
Vol.13 (1), 2010 |
Number 12
Vol.12 (2), 2009 |
Number 12
Vol.12 (1), 2009 |
Number 11
Vol.11 (2),2008 |
Number 11
Vol.11 (1),2008 |
Number 10
Vol.10 (2), 2007 |
Number 10
10 (1),2007 |
Number 9
1&2, 2006 |
Number 9
3&4, 2006 |
Number 8
1&2, 2005 |
Number 8
3&4, 2004 |
Number 7
1&2, 2004 |
Number 6
3&4, 2003 |
Number 6
1&2, 2003 |
Number 5
3&4, 2002 |
Number 5
1&2, 2002 |
Number 4
Vol.3 (4), 2000 |
Number 4
Vol.2 (4), 1999 |
Number 4
Vol.1 (4), 1998 |
Number 4
3&4, 2001 |
Number 4
1&2, 2001 |
Number 3
Vol.3 (3), 2000 |
Number 3
Vol.2 (3), 1999 |
Number 3
Vol.1 (3), 1998 |
Number 2
Vol.3(2), 2000 |
Number 2
Vol.1 (2), 1998 |
Number 2
Vol.2 (2), 1999 |
Number 1
Vol.3 (1), 2000 |
Number 1
Vol.2 (1), 1999 |
Number 1
Vol.1 (1), 1998 |
|
|
