THE ROLE OF RNA METABOLISM
IN NEUROLOGICAL DISEASES
Alaqeel AM1,2,*, Abou Al-Shaar H3, Shariff RK3, Albakr A2
*Corresponding Author: Ahmed M. Alaqeel, M.D., Department of Neurosurgery, University of Calgary,
1403 29th Street NW, Calgary, Alberta T2N 2T9, Canada. Tel: +403-970-9117. Fax: +403-270-7878. E-mail:
ahmedalaqeel@hotmail.com
page: 5
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Abstract
Neurodegenerative disorders are commonly encountered
in medical practices. Such diseases can
lead to major morbidity and mortality among the
affected individuals. The molecular pathogenesis of
these disorders is not yet clear. Recent literature has
revealed that mutations in RNA-binding proteins are
a key cause of several human neuronal-based diseases.
This review discusses the role of RNA metabolism
in neurological diseases with specific emphasis on
roles of RNA translation and microRNAs in neurodegeneration,
RNA-mediated toxicity, repeat expansion
diseases and RNA metabolism, molecular pathogenesis
of amyotrophic lateral sclerosis and frontotemporal
dementia, and neurobiology of survival motor
neuron (SMN) and spinal muscular atrophy.
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