Balkan Journal of Medical Genetics

MOLECULAR CYTOGENETIC STUDY OF THE NF2 GENE DELETION IN MENINGIOMA IN SUDANESE PATIENTS
AbdElmontalab Farah Y1, Fadl Elmula I2, Abushama HM1, Kreskowski K3, Liehr T3,*
*Corresponding Author: Dr. Thomas Liehr, Institut für Humangenetik, Kollegiengasse 10, D-07740 Jena, Germany; Tel.: 49-3641-935533; Fax: ++49-3641-935582; E-mail: Thomas.Liehr@med.uni-jena.de
page: 29

DISCUSSION

In agreement with the literature, the banding cytogenetic approach led to more comprehensive results but was less successful in terms of cell cultivation and growth in almost 70.0% of the cases [8,9]. Besides chromosome 22, involvement of chromosomes 5, 6, 8, 10, 11 and 14 was observed in the present study. Even though involvement of chromosomes 8 and 10 are rather unusual findings [10], chromosome 5, 6, 11 and 14 are known to be involved in menigiomal chromosomal rearrangements [11]. In the present study, statistically there was no significant variation between gender/age and NF2 gene deletion as initiator in tumorigenesis. This might be explained by small samples size, as previous studies demonstrated clear female predominance [12]. However, it may also be an influence of genetic background of Sudanese patients; a comparable rate of 97.0% of meningiomas with NF2 deletions has not yet been found in other ethnicities. Two points that would need more comparison studies for clarification, as comparable studies found loss of NF2 only in ~60.0% of the studied patients [13]. This may have different reasons such as small sample size. However, neither an influence of ethnic background nor of young age of the studied patients (on average ~37 years) can be neglected. This study shows that even in known clinical entities more studies especially from African countries are necessary.

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