Balkan Journal of Medical Genetics

MOLECULAR CYTOGENETIC STUDY OF THE NF2 GENE DELETION IN MENINGIOMA IN SUDANESE PATIENTS
AbdElmontalab Farah Y1, Fadl Elmula I2, Abushama HM1, Kreskowski K3, Liehr T3,*
*Corresponding Author: Dr. Thomas Liehr, Institut für Humangenetik, Kollegiengasse 10, D-07740 Jena, Germany; Tel.: 49-3641-935533; Fax: ++49-3641-935582; E-mail: Thomas.Liehr@med.uni-jena.de
page: 29

RESULTS

In 10 of the 29 meningioma samples, cell cultivation led to successful karyotyping. The banding cytogenetic results are shown in Table 1. Representative I-FISH results are shown in Figure 1. In all but one sample, deletions of NF2 were observed, in 60.0-100.0% of the interphase nuclei studied. In six of the cases the signal pattern indicated an interstitial or terminal deletion of 22q including the NF2 gene region (Figure 1B), in the other 22 cases the signals indicated the complete loss of a chromosome 22 (Figure 1C, Table 1). Statistical analysis of the NF2 gene deletion against age and gender did not reveal any correlation (results not shown).

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