CYTOGENETIC AND MORPHOLOGICAL ANALYSIS
OF DE NOVO ACUTE MYELOID LEUKEMIA IN ADULTS:
A SINGLE CENTER STUDY IN JORDAN
Ayesh MH1, Khassawneh B, Matalkah I, Alawneh K, Jaradat S
*Corresponding Author: Dr. Mahmoud H. Ayesh (Haj Yousef), Department of Internal Medicine, King
Abdullah University Hospital, Faculty of Medicine, Jordan University of Science and Technology, P.O.
Box 3030 Irbid 22110, The Hashemite Kingdom of Jordan; Tel.: +962-2-7200-600, Ext. 40713; Fax: +962-
2-7095-123; E- Mail address: ayesh_mahmoud@yahoo.com
page: 5
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RESULTS
Patient Data. Cytogenetic analyses were carried
out on 35 consecutive adult de novo AML patients
between Septembers 2002 and April 2010.
Three patients did not have metaphases due to the
presence hypocellular marrow with the AML and
one patient had bone marrow necrosis. Thirty-one
patients were included in the analysis. The median
age at diagnosis was 39 years (mean 40.3 years,
range 16-73 years). The male to female ratio was
(65% males:35% females).
Morphological Features of Acute Myeloid
Leukemia. According to the FAB classifi cation,
the morphological subtypes of AML were M5 (17
patients; 55%), M3 (six patients; 19%), M4 (four
patients; 13%), M2 (three patients; 10%), and M0
(one patient; 3%). In the M5 subtype group, 12 patients
were males (71%).
Cytogenetic Analysis. Cytogenetic abnormalities
were observed in 20 patients (65%). Median
age was 35.5 years (range 16-49 years) and male
to female ratio was (60%: 40%). The most common
translocation, t(15;17), was found in six patients
(19%), t(11;17) (two patients; 6%), t (9;11)
(one patient; 3%) and t(7;14) (one patient; 3%). The
inv(16) anomaly was seen in four patients (13%),
inv(11) in one (3%), inv(9) in one (3%) and inv(1)
in one (3%). Trisomy 8 was the most frequent numerical
chromosomal abnormality (four patients;
13%). Trisomy 22 was found in two patients (6%)
and trisomy in one patient (3%). Of the losses of
chromosomal material, del 7 was seen in one patient
(3%) and del 11 in one patient (3%). Sole
karyotype abnormalities were observed in 16/31
patients (52%) and karyotypes with combination
of abnormalities were observed in 4/31 patients
(13%). A few unusual abnormalities were observed
in our study (Table 1).
Normal karyotypes were observed in 11 patients
(35%). The median age was 51 years (range
25-73 years). According to the FAB classifi cation,
nine patients had M5 and two had M2 (Table 2).
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