CYTOGENETIC AND MORPHOLOGICAL ANALYSIS
OF DE NOVO ACUTE MYELOID LEUKEMIA IN ADULTS:
A SINGLE CENTER STUDY IN JORDAN
Ayesh MH1, Khassawneh B, Matalkah I, Alawneh K, Jaradat S
*Corresponding Author: Dr. Mahmoud H. Ayesh (Haj Yousef), Department of Internal Medicine, King
Abdullah University Hospital, Faculty of Medicine, Jordan University of Science and Technology, P.O.
Box 3030 Irbid 22110, The Hashemite Kingdom of Jordan; Tel.: +962-2-7200-600, Ext. 40713; Fax: +962-
2-7095-123; E- Mail address: ayesh_mahmoud@yahoo.com
page: 5
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Abstract
Acute myeloid leukemia (AML) in adults is
known to be a heterogeneous disease with diverse
chromosomal abnormalities. Some of these abnormalities
are found with a high incidence in specifi c
ethnic groups and in certain geographical areas. We
report the results of cytogenetic studies of 35 adult
Jordanian Arab patients with de novo AML diagnosed
according to the French-American-British
(FAB) criteria. Four patients did not have metaphases
secondary to hypocellular bone marrow.
The most common morphological subtype was M5
(55%) followed by M3 (19%). Cytogenetic abnormalities
were present in 20 patients (65%); t(15;17)
translocation in six patients (19%), inv(16) in four
patients (13%), t(11;17) in two patients (4%), and
the t(8;21) translocation was not present in any patient.
Trisomy 8 was the most common numerical
chromosomal abnormality [four patients (13%)].
There were variations and similarities with similar
ethninc Arab populations. The most common
chromosomal abnormalities were t(15;17), +8 and
inv(16). Further and larger crossborder studies are
needed.
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