CYTOGENETIC AND MORPHOLOGICAL ANALYSIS
OF DE NOVO ACUTE MYELOID LEUKEMIA IN ADULTS:
A SINGLE CENTER STUDY IN JORDAN
Ayesh MH1, Khassawneh B, Matalkah I, Alawneh K, Jaradat S
*Corresponding Author: Dr. Mahmoud H. Ayesh (Haj Yousef), Department of Internal Medicine, King
Abdullah University Hospital, Faculty of Medicine, Jordan University of Science and Technology, P.O.
Box 3030 Irbid 22110, The Hashemite Kingdom of Jordan; Tel.: +962-2-7200-600, Ext. 40713; Fax: +962-
2-7095-123; E- Mail address: ayesh_mahmoud@yahoo.com
page: 5
|
|
INTRODUCTION
Acute myeloid leukemia (AML) is a group of
malignant disorders characterized by proliferation
and accumulation of immature hematopoietic cells in
the bone marrow and the blood. Cytogentic fi ndings
in AML are common (50-60%) and are considered to
be important prognostic and diagnostic factors [1,2].
Geographical, ethnic, and environmental infl uences
on the clinical and biological features of AML
is crucial in determining the cytogenetic and morphological
features of this disease [3-8]. Reports on
the cytogenetic and morphological features of AML
from Arab populations are scarce [5,8,9]. Roberts
et al. [5] reported 125 adults with AML from Saudi
Arabia, where karyotypic abnormalities were seen
in 104 patiets (52%) and trisomy 8 being the most
common abnormality. In a study from Kuwait on
45 patients with AML, chromosomal abnormalities
were reported in 73%, and the most common abnormality
was t(15,17) in 18% [8]. In 63 ethnic Omani
patients with AML, chromosome abnormalities
were present in 62%, and the most common abnormalities
were t(8:21) in 11%, t(15,17) in 10% and
trisomy 8 in 11% [9]. The aim of this study was to
report the cytogenetic and morphological features
of de novo AML in adult Jordanian Arabs, and to
compare the results with similar ethnic Arab populations
in other parts of the world.
|
|
|
|
 |
Number 27
VOL. 27 (2), 2024 |
Number 27
VOL. 27 (1), 2024 |
Number 26
Number 26 VOL. 26(2), 2023 All in one |
Number 26
VOL. 26(2), 2023 |
Number 26
VOL. 26, 2023 Supplement |
Number 26
VOL. 26(1), 2023 |
Number 25
VOL. 25(2), 2022 |
Number 25
VOL. 25 (1), 2022 |
Number 24
VOL. 24(2), 2021 |
Number 24
VOL. 24(1), 2021 |
Number 23
VOL. 23(2), 2020 |
Number 22
VOL. 22(2), 2019 |
Number 22
VOL. 22(1), 2019 |
Number 22
VOL. 22, 2019 Supplement |
Number 21
VOL. 21(2), 2018 |
Number 21
VOL. 21 (1), 2018 |
Number 21
VOL. 21, 2018 Supplement |
Number 20
VOL. 20 (2), 2017 |
Number 20
VOL. 20 (1), 2017 |
Number 19
VOL. 19 (2), 2016 |
Number 19
VOL. 19 (1), 2016 |
Number 18
VOL. 18 (2), 2015 |
Number 18
VOL. 18 (1), 2015 |
Number 17
VOL. 17 (2), 2014 |
Number 17
VOL. 17 (1), 2014 |
Number 16
VOL. 16 (2), 2013 |
Number 16
VOL. 16 (1), 2013 |
Number 15
VOL. 15 (2), 2012 |
Number 15
VOL. 15, 2012 Supplement |
Number 15
Vol. 15 (1), 2012 |
Number 14
14 - Vol. 14 (2), 2011 |
Number 14
The 9th Balkan Congress of Medical Genetics |
Number 14
14 - Vol. 14 (1), 2011 |
Number 13
Vol. 13 (2), 2010 |
Number 13
Vol.13 (1), 2010 |
Number 12
Vol.12 (2), 2009 |
Number 12
Vol.12 (1), 2009 |
Number 11
Vol.11 (2),2008 |
Number 11
Vol.11 (1),2008 |
Number 10
Vol.10 (2), 2007 |
Number 10
10 (1),2007 |
Number 9
1&2, 2006 |
Number 9
3&4, 2006 |
Number 8
1&2, 2005 |
Number 8
3&4, 2004 |
Number 7
1&2, 2004 |
Number 6
3&4, 2003 |
Number 6
1&2, 2003 |
Number 5
3&4, 2002 |
Number 5
1&2, 2002 |
Number 4
Vol.3 (4), 2000 |
Number 4
Vol.2 (4), 1999 |
Number 4
Vol.1 (4), 1998 |
Number 4
3&4, 2001 |
Number 4
1&2, 2001 |
Number 3
Vol.3 (3), 2000 |
Number 3
Vol.2 (3), 1999 |
Number 3
Vol.1 (3), 1998 |
Number 2
Vol.3(2), 2000 |
Number 2
Vol.1 (2), 1998 |
Number 2
Vol.2 (2), 1999 |
Number 1
Vol.3 (1), 2000 |
Number 1
Vol.2 (1), 1999 |
Number 1
Vol.1 (1), 1998 |
|
|
