ASSOCIATION OF GLUTATHIONE-S-TRANSFERASE
(GSTM1 and GSTT1) AND FTO GENE POLYMORPHISMS
WITH TYPE 2 DIABETES MELLITUS CASES
IN NORTHERN INDIA
Raza ST, Abbas S, Ahmad A, Ahmed F, Zaidi ZH, Mahdi F
*Corresponding Author: Syed Tasleem Raza, Ph.D., Molecular Biology Laboratory, Department of Biochemistry,
Era’s Lucknow Medical College and Hospital, Hardoi Road, Lucknow, Uttar Pradesh, India 226025. Tel.: +91-522-
240-8122; 240-8123. Fax: +91-522-240-7824. E-mail: tasleem24@gmail.com
page: 47
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Abstract
Type 2 diabetes mellitus (T2DM) is growing in
an epidemic manner across the world and India has
the world’s largest number of diabetic subjects. The
present study was carried out to investigate the association
of glutathione-S-transferase (GSTM1,
GSTT1) and fat mass and obesity associated (FTO)
gene polymorphisms with T2DM patients and controls,
and its role in increasing the susceptibility to
T2DM. A total of 198 subjects (101 T2DM patients
and 97 controls) participated in this study. GSTM1,
GSTT1 and FTO gene polymorphisms in the patients
and controls were evaluated by polymerase
chain reaction (PCR) and restriction fragment length
polymorphism (RFLP). We observed significant association
of GSTM1 positive (p = 0.046) and GSTM1
null (p = 0.046) genotypes with T2DM, while no
significant association was found with the FTO gene
polymorphism in our study. It seems that the GSTM1
gene polymorphism can be a predictive marker for
early identification of a population at risk of T2DM.
The potential role of GST and FTO gene polymorphisms
as a marker of susceptibility to T2DM needs
further studies in a larger number of patients.
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