ADIPOCYTE “FATTY ACID BINDING PROTEIN”
GENE POLYMORPHISMS (rs1054135, rs16909196
AND rs16909187) IN JORDANIANS WITH OBESITY
AND TYPE 2 DIABETES MELLITUS
El-Ryalat S.W.1, Irshaid Y.M.1*, Abujbara M.2, El-Khateeb M.2, Ajlouni K.M.2
*Corresponding Author: Prof. Yacoub M. Irshaid MD, PhD, Department of Pharmacology, College of
Medicine, The University of Jordan, Amman 11942, Jordan. Phone No.: +962 777818284,
Fax No.: +962 6 5300820, Email Addresses: y.irshaid@ju.edu.jo
page: 63
|
|
REFERENCES
1. Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor
F, Bales VS, et al. Prevalence of obesity, diabetes,
and obesity-related health risk factors 2001. JAMA.
2003; 289: 76-79.
2. Furuhashi M, Saitoh S, Shimamoto K, Miura T. Fatty
Acid-Binding Protein 4 (FABP4): Pathophysiological
Insights and Potent Clinical Biomarker of Metabolic
and Cardiovascular Diseases. Clin Med Insights: Cardiol.
2014; 8(S3): 23-33.
3. Khalyfa A, Bhushan B, Hegazi M, Kim J, Kheirandish-
Gozal L, Bhattacharjee R, et al. Fatty-acid binding
protein 4 gene variants and childhood obesity:
potential implications for insulin sensitivity and CRP
levels. Lipids Health Dis. 2010; 9:18. http://www.
lipidworld.com/content/9/1/18.
4. Lee C-H, Lui DTW, Lam KSL. Adipocite Fatty Acid-
Binding Protein, Cardiovascular Disease and Mortality.
Front Immunol. 2021; 12: Article 589206.
5. Xiao Y, Xiao X, Xu A, Chen X, Tang W, Zhou Z. Circulating
adipocyte fatty acid-binding protein levels
predict the development of subclinical atherosclerosis
in type 2 diabetes. J Diabetes Complicat. 2018;
32:1100-1104.
6. Tso AWK, Xu A, Sham PC, Wat NMS, Wang Y, Fong
CHY, et al. Serum Adipocyte Fatty Acid–Binding
Protein as a New Biomarker Predicting the Development
of Type 2 Diabetes. A 10-year prospective
study in a Chinese cohort. Diabetes Care. 2007; 30
(10): 2667-2672.
7. Hardaway AL, Podgorski I. IL-1β, RAGE and FABP4:
targeting the dynamic trio in metabolic inflammation
and related pathologies. Future Med Chem. 2013;
5(10): 1089-1108.
8. Furuhashi M, Hotamisligil GS. Fatty acid-binding proteins:
role in metabolic diseases and potential as drug
targets. Nat Rev Drug Discov. 2008; 7(6): 489-503.
9. Floresta G, Pistarà V, Amata E, Dichiara M, Marrazzo
A, Prezzavento O, et al. Adipocyte fatty acid binding
protein 4 (FABP4) inhibitors. A comprehensive systemic
review. Eur J Med Chem. 2017; 138: 854-873.
10. Lee MYK, Li H, Xiao Y, Zhou Z, Xu A, Vanhoutte
PM. Chronic administration of BMS309403 improves
endothelial function in apolipoprotein E-deficient
mice and cultured human endothelial cells. Br J Pharmacol.
2011; 162: 1564-1576.
11. Lin W, Huang X, Zhang L, Chen D, Wang D, Peng
Q, et al. BMS309403 stimulates glucose uptake in
myotubes through activation of AMP-activated protein
kinase. PLoS ONE. 2012; 7(8): e44570.
12. Furuhashi M, Sakuma I, Morimoto T, Higashiura Y,
Sakai A, Matsumoto M, et al. Treatment with anagliptin,
a DDP-4 inhibitor, decreases FABP4 concentration
in patients with type 2 diabetes mellitus at a
high risk for cardiovascular disease who are receiving
statin therapy. Cardiovasc Diabetol. 2020; 19: 89.
13. Song J, Ren P, Zhang L, Wang XL, Chen L, Shen
YH. Metformin reduces lipid accumulation in macrophages
by inhibiting FOXO1-mediated transcription
of fatty acid-binding protein 4. Biochem Biophys
Res Commun. 2010; 393: 89-94.
14. Mansego ML, Martinez F, Martinez-Larrad MT, Zabena
C, Rojo G, Morcillo S, et al. Common Variants
of the Liver Fatty Acid Binding Protein Gene Influence
the risk of Type 2 Diabetes and Insulin Resistance
in Spanish Population. PLoS ONE. 2012; 7(3):
e31853.
15. Furuhashi M, Mita T, Moniwa N, Hoshina K, Ishimura
S, Fuseya T, et al. Angiotensin II receptor blockers
decrease serum concentration of fatty acid-binding
protein 4 in patients with hypertension. Hypertens
Res. 2015; 38: 252-259.
16. Tuncman G, Erbay E, Hom X, De Vivo I, Campos
H, Rimm EB, et al. A genetic variant at the fatty
acid-binding protein aP2 locus reduces the risk for
hypertriglyceridemia, type 2 diabetes, and cardiovascular
disease. PNAS. 2006; 103(18): 6970-2975.
17. Mukamal KJ, Wilk JB, Biggs ML, Jensen MK, Ix JH,
Kizer JR, et al. Common FABP4 Genetic Variants
and Plasma Levels of Fatty Acid Binding Protein 4
in Older Adults. Lipids. 2013; 48(11): 1169-1175.
18. Tönjes A, Kralisch S, Lössner U, Kovacs P, Blüher M,
Stumvoll M, et al. Metabolic and genetic predictors
of circulating adipocyte fatty acid-binding protein.
Int J Obes. 2012; 36(6): 766-773.
19. Lucena-Aguilar G, Sánchez-López AM, Barberán-
Aceituno C, Carrillo-Ávila JA, López-Guerrero
JA, Aguilar-Quesada R. DNA Source Selection for
Downstream Applications Based on DNA Quality Indicators
Analysis. Biopreserv Biobank. 2016; 14(4):
264-270.
20. Chan K-H K, Song Y, Hsu Y-H, You N-CY, Tinker LF,
Liu S. Common Genetic Variants in Fatty Acid–Binding
Protein-4 (FABP4) and Clinical Diabetes Risk in
the Women’s Health Initiative Observational study.
Obes. 2010; 18(9):1812–1820.
|
|
|
|
 |
Number 27
VOL. 27 (2), 2024 |
Number 27
VOL. 27 (1), 2024 |
Number 26
Number 26 VOL. 26(2), 2023 All in one |
Number 26
VOL. 26(2), 2023 |
Number 26
VOL. 26, 2023 Supplement |
Number 26
VOL. 26(1), 2023 |
Number 25
VOL. 25(2), 2022 |
Number 25
VOL. 25 (1), 2022 |
Number 24
VOL. 24(2), 2021 |
Number 24
VOL. 24(1), 2021 |
Number 23
VOL. 23(2), 2020 |
Number 22
VOL. 22(2), 2019 |
Number 22
VOL. 22(1), 2019 |
Number 22
VOL. 22, 2019 Supplement |
Number 21
VOL. 21(2), 2018 |
Number 21
VOL. 21 (1), 2018 |
Number 21
VOL. 21, 2018 Supplement |
Number 20
VOL. 20 (2), 2017 |
Number 20
VOL. 20 (1), 2017 |
Number 19
VOL. 19 (2), 2016 |
Number 19
VOL. 19 (1), 2016 |
Number 18
VOL. 18 (2), 2015 |
Number 18
VOL. 18 (1), 2015 |
Number 17
VOL. 17 (2), 2014 |
Number 17
VOL. 17 (1), 2014 |
Number 16
VOL. 16 (2), 2013 |
Number 16
VOL. 16 (1), 2013 |
Number 15
VOL. 15 (2), 2012 |
Number 15
VOL. 15, 2012 Supplement |
Number 15
Vol. 15 (1), 2012 |
Number 14
14 - Vol. 14 (2), 2011 |
Number 14
The 9th Balkan Congress of Medical Genetics |
Number 14
14 - Vol. 14 (1), 2011 |
Number 13
Vol. 13 (2), 2010 |
Number 13
Vol.13 (1), 2010 |
Number 12
Vol.12 (2), 2009 |
Number 12
Vol.12 (1), 2009 |
Number 11
Vol.11 (2),2008 |
Number 11
Vol.11 (1),2008 |
Number 10
Vol.10 (2), 2007 |
Number 10
10 (1),2007 |
Number 9
1&2, 2006 |
Number 9
3&4, 2006 |
Number 8
1&2, 2005 |
Number 8
3&4, 2004 |
Number 7
1&2, 2004 |
Number 6
3&4, 2003 |
Number 6
1&2, 2003 |
Number 5
3&4, 2002 |
Number 5
1&2, 2002 |
Number 4
Vol.3 (4), 2000 |
Number 4
Vol.2 (4), 1999 |
Number 4
Vol.1 (4), 1998 |
Number 4
3&4, 2001 |
Number 4
1&2, 2001 |
Number 3
Vol.3 (3), 2000 |
Number 3
Vol.2 (3), 1999 |
Number 3
Vol.1 (3), 1998 |
Number 2
Vol.3(2), 2000 |
Number 2
Vol.1 (2), 1998 |
Number 2
Vol.2 (2), 1999 |
Number 1
Vol.3 (1), 2000 |
Number 1
Vol.2 (1), 1999 |
Number 1
Vol.1 (1), 1998 |
|
|
