Balkan Journal of Medical Genetics

DO WE USE METHYLATION OF NFATC1 AND FOS GENES AS A BIOMARKER FOR POSTMENOPAUSAL OSTEOPOROSIS?
Kalkan R, Tosun O
*Corresponding Author: Associate Professor Rasime Kalkan, Department of Medical Genetics, Faculty of Medicine, Near East University, Near East Boulevard, Nicosia, Cyprus, 99138. Tel: +903-92- 223-6464. Fax: +903-92-223-6461. E-mail: rasime.kalkan@neu.edu.tr, kalkanr@yahoo.com
page: 35

RESULTS

The mean age of 30 premenopause patients was 33.5 ± 6.9 years and the mean age of 35 postmenopause patients was 56.7 ± 4.9 years. There were no significant differences between the premenopausal and postmenopausal group in bone mineral density (BMD) (p >0.005). The NFATC1 promotor methylation was detected in 11 of the 35 postmenopausal women (31.4%) (Figure 1) and unmethylated in 24 of the 35 postmenopausal women (68.8%). The NFATC1 promotor methylation was detected in 19 of the 30 (63.3%) control sample (premenopausal women) and unmethylated in 11 of the 30 control sample (36.7%). Here, we found statistically significant correlation between postmenopause and unmethylation of NFATC1 promotor (p = 0.010). The FOS promotor methylation was detected in six of the 35 (17.1%) postmenopausal women (Figure 2) and unmethylated in 29 of the 35 postmenopausal women (82.9%) (p >0.005). The FOS promotor methylation was detected in five of the 30 (16.7%) control sample (premenopausal women) and unmethylated in 25 of the 30 control sample (83.3%). Moreover, there was no statistically significant association identified between menopause and methylation status (p >0.05) (Table 1).

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