DO WE USE METHYLATION OF NFATC1 AND FOS GENES AS
A BIOMARKER FOR POSTMENOPAUSAL OSTEOPOROSIS?
Kalkan R, Tosun O
*Corresponding Author: Associate Professor Rasime Kalkan, Department of Medical Genetics, Faculty
of Medicine, Near East University, Near East Boulevard, Nicosia, Cyprus, 99138. Tel: +903-92-
223-6464. Fax: +903-92-223-6461. E-mail: rasime.kalkan@neu.edu.tr, kalkanr@yahoo.com
page: 35
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Abstract
Genetic and epigenetic factors have an important role
during the development of osteoporosis. Receptor activator
of nuclear factor-κ B (NF-κB) (RANK)/receptor activator
of NF-κB ligand (RANKL) pathway is important for the
bone remodeling, and NFATC1 and FOS are the downtargets
of this pathway. Here, we report methylation status
of NFATC1 and FOS genes in post- and premenopausal
women. In this study, 30 premenopausal and 35 postmenopausal
women were included. Methylation sensitive-high
resolution melting (MS-HRM) analysis was used for identification
of NFATC1 and FOS genes methylation. The
NFATC1 gene was methylated in 11 of the 35 postmenopausal
women, and the FOS gene was methylated in six
of the postmenopausal women (p >0.005). Here, we found
statistically significant association between unmethylation
of the NFATC1 gene and postmenopausal status. This result
explains the epigenetic regulation of osteoclasts during the
menopausal transition, and for the first time, our results
can be used for epigenetic explanation of postmenopausal
osteoporosis in the literature. However, the limited
number of studies in this field makes our results crucial.
Our results showed great value of epigenetic profiles of
postmenopausal women.
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