EPIGENETIC SIGNATURE OF CHRONIC MATERNAL STRESS
LOAD DURING PREGNANCY MIGHT BE A POTENTIAL
BIOMARKER FOR SPONTANEOUS PRETERM BIRTH
Rogac M, Peterlin B
*Corresponding Author: Mihael Rogac, M.D., Ph.D., Clinical Institute of Medical Genetics, University
Medical Center Ljubljana, Slajmerjeva 4, 1000 Ljubljana, Slovenia. Tel: +386-1-522-6171.
Fax: +386-1-540-1137. E-mail: mihael.rogac@kclj.si
page: 27
|
|
REFERENCES
1. Goldenberg RL, Rouse DJ. Prevention of premature
birth. N Engl J Med. 1998; 339(5): 313-320.
2. Goldenberg RL, Culhane JF, Iams JD, Romero R.
Epidemiology and causes of preterm birth. Lancet.
2008; 371(9606): 75-84.
3. Coletti MF, Caravale B, Gasparini C, Franco F, Campi
F, Dotta A. One-year neurodevelopmental outcome
of very and late preterm infants: Risk factors and
correlation with maternal stress. Infant Behav Dev.
2015; 39(5): 11-20.
4. Gennaro S, Hennessy MD. Psychological and physiological
stress: Impact on preterm birth. J Obstet Gynecol
Neonatal Nurs. 2003; 32(5): 668-675.
5. Lobel M, Cannella DL, Graham JE, DeVincent C,
Schneider J, Meyer BA. Pregnancy-specific stress,
prenatal health behaviors, and birth outcomes. Health
Psychol. 2008; 27(5): 604-615.
6. Harville EW, Savitz DA, Dole N, Herring AH, Thorp
JM. Stress questionnaires and stress biomarkers during
pregnancy. J Womens Health (Larchmt). 2009;
18(9): 1425-1433.
7. Kramer MS, Lydon J, Goulet L, Kahn S, Dahhou M,
Platt RW, et al. Maternal stress/distress, hormonal
pathways and spontaneous preterm birth. Paediatr
Perinat Epidemiol. 2013; 27(3): 237-246.
8. Vidal AC, Benjamin Neelon SE, Liu Y, Tuli AM,
Fuemmeler BF, Hoyo C, et al. Maternal stress, preterm
birth, and DNA methylation at imprint regulatory
sequences in humans. Genet Epigenet. 2014;
6(9): 37-44.
9. Scott EM, Thomson AM. A psychological investigation
of primigravidae. IV. Psychological factors and
the clinical phenomena of labour. J Obstet Gynaecol
Br Emp. 1956; 63(4): 502-508.
10. Wortis H, Freedman AM. Maternal stress and premature
delivery. Bull World Health Organ. 1962; 26:
285-291.
11. Rubin LP. Maternal and pediatric health and disease:
Integrating biopsychosocial models and epigenetics.
Pediatr Res. 2016; 79(1-2): 127-135.
12. Staneva A, Bogossian F, Pritchard M, Wittkowski A.
The effects of maternal depression, anxiety, and perceived
stress during pregnancy on preterm birth: A
systematic review. Women Birth. 2015; 28(3): 179-193.
13. Sanchez SE, Puente GC, Atencio G, Qiu C, Yanez D,
Gelaye B, et al. Risk of spontaneous preterm birth
in relation to maternal depressive, anxiety, and stress
symptoms. J Reprod Med. 2013; 58(1-2): 25-33.
14. McDonald SW, Kingston D, Bayrampour H, Dolan
SM, Tough SC. Cumulative psychosocial stress, coping
resources, and preterm birth. Arch Womens Ment
Health. 2014; 17(6): 559-568.
15. Manuck TA, Esplin MS, Biggio J, Bukowski R, Parry
S, Zhang H, et al. The phenotype of spontaneous pre term birth: Application of a clinical phenotyping tool.
Am J Obstet Gynecol. 2015; 212(4): 487.e1-487.e11.
16. Braithwaite EC, Kundakovic M, Ramchandani PG,
Murphy SE, Champagne FA. Maternal prenatal depressive
symptoms predict infant NR3C1 1F and
BDNF IV DNA methylation. Epigenetics. 2015;
10(5): 408-417.
17. Conradt E, Fei M, LaGasse L, Tronick E, Guerin
D, Gorman D, et al. Prenatal predictors of infant
self-regulation: The contributions of placental DNA
methylation of NR3C1 and neuroendocrine activity.
Front Behav Neurosci. 2015; 9(5): 130-135.
18. Schechter DS, Moser DA, Paoloni-Giacobino A,
Stenz L, Gex-Fabry M, Aue T, et al. Methylation of
NR3C1 is related to maternal PTSD, parenting stress
and maternal medial prefrontal cortical activity in
response to child separation among mothers with
histories of violence exposure. Front Psychol. 2015;
6(5): 690-702.
19. Mulligan CJ, D’Errico NC, Stees J, Hughes DA.
Methylation changes at NR3C1 in newborns associate
with maternal prenatal stress exposure and newborn
birth weight. Epigenetics. 2012; 7(8): 853-857.
20. Perroud N, Paoloni-Giacobino A, Prada P, Olie E,
Salzmann A, Nicastro R, et al. Increased methylation
of glucocorticoid receptor gene (NR3C1) in adults
with a history of childhood maltreatment: A link with
the severity and type of trauma. Transl Psychiatry.
2011; 1(12): e59-e68.
21. Non AL, Binder AM, Barault L, Rancourt RC, Kubzansky
LD, Michels KB. DNA methylation of stressrelated
genes and LINE-1 repetitive elements across
the healthy human placenta. Placenta. 2012; 33(3):
183-187.
22. Provenzi L, Fumagalli M, Sirgiovanni I, Giorda R,
Pozzoli U, Morandi F, et al. Pain-related stress during
the Neonatal Intensive Care Unit stay and SLC6A4
methylation in very preterm infants. Front Behav
Neurosci. 2015; 9(4): 99-108.
23. Paquette AG, Lester BM, Koestler DC, Lesseur C,
Armstrong DA, Marsit CJ. Placental FKBP5 genetic
and epigenetic variation is associated with infant neurobe-
havioral outcomes in the RICHS cohort. PLoS
One. 2014; 9(8): e104913.
24. O’Donnell KJ, Meaney MJ. Fetal origins of mental
health: The developmental origins of health and
disease hypothesis. Am J Psychiatry. 2017; 174(4):
319-328.
25. Chapman K, Holmes M, Seckl J. 11Beta-hydroxysteroid
dehydrogenases: Intracellular gate-keepers
of tissue glucocorticoid action. Physiol Rev. 2013;
93(3): 1139-1206.
26. Champagne FA, Weaver IC, Diorio J, Dymov S, Szyf
M, Meaney MJ. Maternal care associated with methylation
of the estrogen receptor-alpha1b promoter
and estrogen receptor-alpha expression in the medial
preoptic area of female offspring. Endocrinology.
2006; 147(6): 2909-2915.
27. Turecki G, Meaney MJ. Effects of the social environment
and stress on glucocorticoid receptor gene
methylation: A systematic review. Biol Psychiatry.
2016; 79(2): 87-96.
28. Paquette AG, Lester BM, Lesseur C, Armstrong DA,
Guerin DJ, Appleton AA, et al. Placental epigenetic
patterning of glucocorticoid response genes is associated
with infant neurodevelopment. Epigenomics.
2015; 7(5): 767-779.
29. D’Addario C, Dell’Osso B, Palazzo MC, Benatti B,
Lietti L, Cattaneo E, et al. Selective DNA methylation
of BDNF promoter in bipolar disorder: differences
among patients with BDI and BDII. Neuropsychopharmacology.
2012; 37(7): 1647-1655.
30. Fuchikami M, Morinobu S, Segawa M, Okamoto Y,
Yamawaki S, Ozaki N, et al. DNA methylation profiles
of the brain-derived neurotrophic factor (BDNF)
gene as a potent diagnostic biomarker in major depression.
PLoS One. 2011; 6(8): e23881.
31. Unternaehrer E, Luers P, Mill J, Dempster E, Meyer
AH, Staehli S, et al. Dynamic changes in DNA methylation
of stress-associated genes (OXTR, BDNF)
after acute psychosocial stress. Transl Psychiatry.
2012; 2(8): e150-e157.
32. Montirosso R, Provenzi L, Fumagalli M, Sirgiovanni
I, Giorda R, Pozzoli U, et al. Serotonin transporter
gene (SLC6A4) methylation associates with Neonatal
Intensive Care Unit stay and 3-month-old temperament
in preterm infants. Child Dev. 2016; 87(1):
38-48.
33. Hillman SL, Finer S, Smart MC, Mathews C, Lowe
R, Rakyan VK, et al. Novel DNA methylation profiles
associated with key gene regulation and transcription
pathways in blood and placenta of growth-restricted
neonates. Epigenetics. 2015; 10(1): 50-61.
34. Sparrow S, Manning JR, Cartier J, Anblagan D, Bastin
ME, Piyasena C, et al. Epigenomic profiling of
preterm infants reveals DNA methylation differences
at sites associated with neural function. Transl Psychiatry.
2016; 6(1): e716-e724.
35. Parets SE, Conneely KN, Kilaru V, Fortunato SJ, Syed
TA, Saade G, et al. Fetal DNA methylation associates with early spontaneous preterm birth and gestational
age. PLoS One. 2013; 8(6): e67489.
36. Cruickshank MN, Oshlack A, Theda C, Davis PG,
Martino D, Sheehan P, et al. Analysis of epigenetic
changes in survivors of preterm birth reveals the effect
of gestational age and evidence for a long term
legacy. Genome Med. 2013; 5(10): 96-108.
37. Fernando F, Keijser R, Henneman P, van der Kevie-
Kersemaekers AM, Mannens MM, van der Post JA,
et al. The idiopathic preterm delivery methylation
profile in umbilical cord blood DNA. BMC Genomics.
2015; 16(9): 736-748.
38. Parets SE, Conneely KN, Kilaru V, Menon R, Smith
AK. DNA methylation provides insight into intergenerational
risk for preterm birth in African Americans.
Epigenetics. 2015; 10(9): 784-792.
39. Heng YJ, Pennell CE, Chua HN, Perkins JE, Lye SJ.
Whole blood gene expression profile associated with
spontaneous preterm birth in women with threatened
preterm labor. PLoS One. 2014; 9(5): e96901.
40. Ewald ER, Wand GS, Seifuddin F, Yang X, Tamashiro
KL, Potash JB, et al. Alterations in DNA meth-ylation
of Fkbp5 as a determinant of blood-brain correlation
of glucocorticoid exposure. Psychoneuroendocrinology.
2014; 44(6): 112-122.
41. Aberg KA, Xie LY, McClay JL, Nerella S, Vunck S,
Snider S, et al. Testing two models describing how
methylome-wide studies in blood are informative
for psychiatric conditions. Epigenomics. 2013; 5(4):
367-377.
42. Murphy BC, O’Reilly RL, Singh SM. Site-specific
cytosine methylation in S-COMT promoter in 31
brain regions with implications for studies involving
schizophrenia. Am J Med Genet B Neuropsychiatr
Genet. 2005; 133B(1): 37-42.
43. Fan S, Zhang X. CpG island methylation pattern in
different human tissues and its correlation with gene
expression. Biochem Biophys Res Commun. 2009;
383(4): 421-425.
44. Davies MN, Volta M, Pidsley R, Lunnon K, Dixit
A, Lovestone S, et al. Functional annotation of the
human brain methylome identifies tissue-specific epigenetic
variation across brain and blood. Genome
Biol. 2012; 13(6): R43-R57.
45. van den Oord EJ, Clark SL, Xie LY, Shabalin AA,
Dozmorov MG, Kumar G, et al. A whole methylome
CpG-SNP association study of psychosis in blood and
brain tissue. Schizophr Bull. 2016; 42(4): 1018-1026.
46. Tylee DS, Kawaguchi DM, Glatt SJ. On the outside,
looking in: A review and evaluation of the comparability
of blood and brain “-omes”. Am J Med Genet
B Neuropsychiatr Genet. 2013; 162B(7): 595-603.
47. Irwin M. Immune correlates of depression. Adv Exp
Med Biol. 1999; 461: 1-24.
48. Maes M, Bosmans E, Calabrese J, Smith R, Meltzer
HY. Interleukin-2 and interleukin-6 in schizophrenia
and mania: Effects of neuroleptics and mood stabilizers.
J Psychiatr Res. 1995; 29(2): 141-152.
49. Schwarz MJ, Müller N, Riedel M, Ackenheil M. The
Th2-hypothesis of schizophrenia: A strategy to identify
a subgroup of schizophrenia caused by immune
mechanisms. Med Hypotheses. 2001; 56(4): 483-486.
50. Felten DL, Felten SY, Bellinger DL, Carlson SL,
Ackerman KD, Madden KS, et al. Noradrenergic
sympathetic neural interactions with the immune system:
Structure and function. Immunol Rev. 1987;
100(12): 225-260.
|
|
|
|
 |
Number 27
VOL. 27 (2), 2024 |
Number 27
VOL. 27 (1), 2024 |
Number 26
Number 26 VOL. 26(2), 2023 All in one |
Number 26
VOL. 26(2), 2023 |
Number 26
VOL. 26, 2023 Supplement |
Number 26
VOL. 26(1), 2023 |
Number 25
VOL. 25(2), 2022 |
Number 25
VOL. 25 (1), 2022 |
Number 24
VOL. 24(2), 2021 |
Number 24
VOL. 24(1), 2021 |
Number 23
VOL. 23(2), 2020 |
Number 22
VOL. 22(2), 2019 |
Number 22
VOL. 22(1), 2019 |
Number 22
VOL. 22, 2019 Supplement |
Number 21
VOL. 21(2), 2018 |
Number 21
VOL. 21 (1), 2018 |
Number 21
VOL. 21, 2018 Supplement |
Number 20
VOL. 20 (2), 2017 |
Number 20
VOL. 20 (1), 2017 |
Number 19
VOL. 19 (2), 2016 |
Number 19
VOL. 19 (1), 2016 |
Number 18
VOL. 18 (2), 2015 |
Number 18
VOL. 18 (1), 2015 |
Number 17
VOL. 17 (2), 2014 |
Number 17
VOL. 17 (1), 2014 |
Number 16
VOL. 16 (2), 2013 |
Number 16
VOL. 16 (1), 2013 |
Number 15
VOL. 15 (2), 2012 |
Number 15
VOL. 15, 2012 Supplement |
Number 15
Vol. 15 (1), 2012 |
Number 14
14 - Vol. 14 (2), 2011 |
Number 14
The 9th Balkan Congress of Medical Genetics |
Number 14
14 - Vol. 14 (1), 2011 |
Number 13
Vol. 13 (2), 2010 |
Number 13
Vol.13 (1), 2010 |
Number 12
Vol.12 (2), 2009 |
Number 12
Vol.12 (1), 2009 |
Number 11
Vol.11 (2),2008 |
Number 11
Vol.11 (1),2008 |
Number 10
Vol.10 (2), 2007 |
Number 10
10 (1),2007 |
Number 9
1&2, 2006 |
Number 9
3&4, 2006 |
Number 8
1&2, 2005 |
Number 8
3&4, 2004 |
Number 7
1&2, 2004 |
Number 6
3&4, 2003 |
Number 6
1&2, 2003 |
Number 5
3&4, 2002 |
Number 5
1&2, 2002 |
Number 4
Vol.3 (4), 2000 |
Number 4
Vol.2 (4), 1999 |
Number 4
Vol.1 (4), 1998 |
Number 4
3&4, 2001 |
Number 4
1&2, 2001 |
Number 3
Vol.3 (3), 2000 |
Number 3
Vol.2 (3), 1999 |
Number 3
Vol.1 (3), 1998 |
Number 2
Vol.3(2), 2000 |
Number 2
Vol.1 (2), 1998 |
Number 2
Vol.2 (2), 1999 |
Number 1
Vol.3 (1), 2000 |
Number 1
Vol.2 (1), 1999 |
Number 1
Vol.1 (1), 1998 |
|
|
