DETERMINING SPECIFIC THYROID TRANSCRIPTS
IN PERIPHERAL BLOOD:
A SINGLE CENTER STUDY EXPERIENCE
Makazlieva T, Eftimov A, Vaskova O, Tripunoski T,
Miladinova D, Risteski S, Jovanovic H, Jakovski Z
Tanja Makazlieva and Aleksandar Eftimov contributed equally to this study
and are considered first coauthors.
*Corresponding Author: Tanja Makazlieva, Ph.D., Institute of Pathophysiology and Nuclear Medicine,
Medical Faculty, Mother Teresa Street, No. 17, 1000, Skopje, Republic of Macedonia.
Mobile: +389-75-313-665. E-mail: tmakazlieva@medf.ukim.edu.mk or tmakazlieva@gmail.com
page: 13
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CONCLUSIONS
Data from our analysis revealed expression of TSHR
and Tg transcripts both in TC patients with incomplete
response to treatment and in HC controls and TC patients
with excellent response to treatment. We found statistically
significant difference in ΔCt value for both target genes.
The TCs patients expressed TSHR-mRNA by a 8.57-fold
higher level than HC individuals and 6.6-fold higher for
Tg-mRNA. The highest fold change of 14.17 in expression
of TSHR-mRNA was found between the TCb group and
HC. Our preliminary study showed significant difference
in TSHR-mRNA and Tg-mRNA expression levels between
TCs patients and HC and TCr group of patients. Further
studies with a larger number of subjects and standardization
of the methodology, especially in quantification,
are needed for understanding the real significance of this
method.
Declaration of Interest. The authors report no conflicts
of interest. The authors alone are responsible for the
content and writing of this article.
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