ASSOCIATION OF THE APOLIPOPROTEIN A-I GENE POLYMORPHISMS WITH CARDIOVASCULAR DISEASE RISK FACTORS AND ATHEROGENIC INDICES IN PATIENTS FROM ASSAM, NORTHEAST INDIA
Bora K1,2,*, Pathak MS2, Borah P3, Hussain Md.I.3, Das D4
*Corresponding Author: : Dr. Kaustubh Bora, Regional Medical Research Centre, Northeast Region, Indian Council of Medical Research (ICMR), P.O. Box 105, Dibrugarh-786001, Assam, India. Tel: +91-943-557-2062. Fax: +91-364-253-8003. E-mail: kaustubhbora1@gmail.com
page: 59
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CONCLUSIONS
The results from our pilot study suggested that the G75A and C+83T polymorphisms of APOA1 were important modulators of CVD risk in the population of Assam. In general, the A allele at G-75A was pro-atherogenic and the C allele at the C+83T locus was anti-atherogenic. The G-75A locus was associated with LDL-C levels, while the C+83T locus was associated with TG and VLDL-C levels. But, these sites were not associated with the HDL-C status. Our study supports the hypothesis that the two SNPs do not play a major role in influencing HDL-C levels. Associations with TC, obesity and BP were also absent. Notably, these two loci were significantly associated with several atherogenic indices that are strong predictors of CVDs. Although drawn on a sample of modest size, yet these remarkable associations (with the detected effect sizes and available statistical power) from our exploratory study strongly suggested that the effect of genetic factors on atherogenic indices may be important while characterizing CVD risk. In the current population, the G-75A polymorphism seemed to be particularly important in this regard. Similar studies in other populations and larger sample groups would help in clarifying such utility of atherogenic indices.
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