FREQUENCY AND ASSOCIATION OF 1691 (G>A) FVL,
20210 (G>A) PT AND 677 (C>T) MTHFR WITH
DEEP VEIN THROMBOSIS IN THE POPULATION
OF BOSNIA AND HERZEGOVINA
Jusić-Karić A, Terzić R, Jerkić Z, Avdić A, Pođanin M
*Corresponding Author: Amela Jusić-Karić, Ph.D., Faculty of Science and Mathematics, University of Tuzla,
Univerzitetska 4, 75 000 Tuzla, Bosnia and Herzegovina. Tel: +387-61-289-217. Fax: +387-35-320-861.
E-mail: amela.jusic @untz.ba
page: 43
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CONCLUSIONS
The frequency of the 1691, 20210 and 677 mutations
in the healthy population in Bosnia and Herzegovina
is similar to previously reported prevalence
of these mutations in other populations in the region.
Based on our results, we can conclude that only the
1691 mutation was significantly associated with
DVT in our population. We did not confirm association
of other two studied mutations, 20210 and 677,
with DVT in the investigated sample of the Bosnian
population. The observed frequency of combined
heterozygosity for the 1691 and 677 mutations in
our study and their possible impact on developing
DVT imply that further studies on a larger number
of patients from all of Bosnia and Herzegovina are
needed for confirmation of our findings.
Declaration of Interest. The authors report no
conflicts of interest. The authors alone are responsible
for the content and writing of this article.
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