THE INFLUENCE OF CYP2C8*3 ON CARBAMAZEPINE SERUM
CONCENTRATION IN EPILEPTIC PEDIATRIC PATIENTS
Milovanovic DD, Milovanovic JR, Radovanovic M, Radosavljevic I,
Obradovic S, Jankovic S, Milovanovic D, Djordjevic N
*Corresponding Author: M.D., Ph.D., Associate Professor, Department of Pharmacology
and Toxicology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34 000 Kragujevac,
Serbia. Tel: +381-34-306-800, ext 223. Fax: +381-34-306-800. E-mail: natashadj2002@yahoo.com
page: 21
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INTRODUCTION
Carbamazepine belongs to the older generation
of anticonvulsants, which is almost completely metabolized
in the liver through processes that involve
several liver enzymes, including CYP2C8 [1-4]. To
date, there are 16 different CYP2C8 alleles described
http://www.cypalleles. ki.se/cyp2c8.htm), most of
them associated with altered enzyme activity [5].
Although genes could affect the drug metabolism
there is a general lack of evidence of influence of
CYP2C8 genetic variations on carbamazepine pharmacokinetics,
especially in children [6]. Since the
drug metabolism in the pediatric population is specific
[7], the extrapolation of knowledge from adults,
without prior evidence of how various factors influence
drug metabolism, may lead to improper management
of pediatric therapy [8]. Therefore, the main
aim of this study was to investigate the effect of the
CYP2C8 genetic polymorphisms on carbamazepine
dosing, serum concentration and clearance, in epileptic
pediatric patients.
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