ASSOCIATION BETWEEN THE CATECHOL-O-METHYLTRANSFERASE Val158Met POLYMORPHISM WITH SUSCEPTIBILITY AND SEVERITY OF CARPAL TUNNEL SYNDROME
Erkol İnal E1,*, Eroğlu P2, Görükmez O3, Özemri Sağ Ş4, Yakut T4
*Corresponding Author: Dr. Esra Erkol İnal, Department of Physical Medicine and Rehabilitation, Süleyman Demirel University, Faculty of Medicine, Afyon yolu, Çünür, Isparta, Turkey. Tel: +90-246-211-9280. GSM: +90-507-563-6511. Fax: +90-246-211-2830. E-mail: esraerkol@hotmail.com
page: 43

REFERENCES

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Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet. 2005; 14(1): 135-143. 14. Segall SK, Maixner W, Belfer I, Wiltshire T, Seltzer Z, Diatchenko L. Janus molecule I: Dichotomous effects of COMT in neuropathic vs nociceptive pain modalities. CNS Neurol Disord Drug Targets. 2012; 11(3): 222-235. 15. Barbosa FR, Matsuda JB, Mazucato M, de Castro França S, Zingaretti SM, da Silva LM, et al. Influence of catechol-O-methyltransferase (COMT) gene polymorphisms in pain sensibility of Brazilian fibromyalgia patients. Rheumatol Int. 2012; 32(2): 427-430. 16. Smith SB, Maixner DW, Greenspan JD, Dubner R, Fillingim RB, Ohrbach R, et al. Potential genetic risk factors for chronic TMD: Genetic associations from the OP PERA case control study. J Pain. 2011; 12(11 Suppl): 92-101. 17. Hagen K, Pettersen E, Stovner LJ, Skorpen F, Zwart JA. No association between chronic musculoskeletal complaints and Val158Met polymorphism in the catechol-O-methyltransferase gene. The HUNT study. BMC Musculoskelet Disord. 2006; 7: 40. 18. Armero P, Muriel C, Santos J, Sànchez-Montero FJ, Rodríguez RE, González-Sarmiento R. COMT (Val158 Met) polymorphism is not associated to neuropathic pain in a Spanish population. Eur J Pain. 2005; 9(3): 229-232. 19. Nicholl BI, Holliday KL, Macfarlane GJ, Thomson W, Davies KA, O’Neill TW, et al.; European Male Ageing Study Group. No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain. Ann Rheum Dis. 2010; 69(11): 2009-2012. 20. Cohen H, Neumann L, Glazer Y, Ebstein RP, Buskila D. The relationship between a common catechol-O-methyltransferase (COMT) polymorphism val(158)met and fibromyalgia. Clin Exp Rheumatol. 2009; 27(5 Suppl 56): 51-56. 21. Fernández-de-Las-Peñas C, Ambite-Quesada S, Gil-Crujera A, Cigarán-Méndez M, Peñacoba- Puente C. Catechol-O-methyltransferase Val- 158Met polymorphism influences anxiety, depression, and disability, but not pressure pain sensitivity, in women with fibromyalgia syndrome. J Pain. 2012; 13(11): 1068-1074. 22. Vargas-Alarcón, JG, Fragoso M, Cruz-Robles D, Vargas A, Vargas A, Lao-Villadóniga JI, et al. Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia. Arthritis Res Ther. 2007; 9(6): 110. 23. Jacobsen LM, Schistad EI, Storesund A, Pedersen LM, Rygh LJ, Røe C, et al. The COMT rs4680 Met allele contributes to long-lasting low back pain, sciatica and disability after lumbar disc herniation. Eur J Pain. 2012; 16(7): 1064-1069. 24. Omair A, Lie BA, Reikeras O, Holden M, Brox JI. Genetic contribution of catechol-O-methyltransferase variants in treatment outcome of low back pain: A prospective genetic association study. BMC Musculoskelet Disord. 2012; 13: 76.



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