ASSOCIATION BETWEEN THE
CATECHOL-O-METHYLTRANSFERASE Val158Met
POLYMORPHISM WITH SUSCEPTIBILITY
AND SEVERITY OF CARPAL TUNNEL SYNDROME
Erkol İnal E1,*, Eroğlu P2, Görükmez O3, Özemri Sağ Ş4, Yakut T4
*Corresponding Author: Dr. Esra Erkol İnal, Department of Physical Medicine and Rehabilitation, Süleyman
Demirel University, Faculty of Medicine, Afyon yolu, Çünür, Isparta, Turkey. Tel: +90-246-211-9280. GSM:
+90-507-563-6511. Fax: +90-246-211-2830. E-mail: esraerkol@hotmail.com
page: 43
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Abstract
Carpal tunnel syndrome (CTS) is the most common
entrapment neuropathy of the upper extremity.
In this study, we aimed to clarify the relationships
between the catechol-O-methyltransferase (COMT)
gene Val158Met (rs4680) polymorphism and development,
functional and clinical status of CTS. Ninetyfive
women with electro diagnostically confirmed
CTS and 95 healthy controls were enrolled in the
study. The functional and clinical status of the patients
was measured by the Turkish version of the Boston
Questionnaire and intensity of pain related to the past
2 weeks was evaluated on a visual analog scale (VAS).
The Val158Met polymorphism was determined using
the polymerase chain reaction-restriction fragment
length polymorphism (PCR-RFLP), method.
We divided patients according to the genotypes of
the Val158Met polymorphism as Val/Val, Val/Met
and Met/Met. There were not any significant differences
in terms of Val158Met polymorphisms between
patients and healthy controls (p >0.05). We also did
not find any relationships between the Val158Met
polymorphism and functional and clinical status of
CTS (p >0.05). In conclusion, although we did not find
any relationships between CTS and the Val158Met
polymorphism, we could not generalize this result to
the general population. Future studies are warranted
to conclude precise associations.
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