MITOCHONDRIAL DNA 4977 bp DELETION
IN CHRONIC CERVICITIS AND CERVIX CANCERS
Kara M, Tatar A, Borekci B, Dagli F, Oztas S
*Corresponding Author: Murat Kara M.D., Department of Genetics, School of Medicine, Firat University,
Universite cad. No. 2, 23119 Elazig, Turkey; Tel: +90-424-233-35-55/1938; Fax: +90-424-238-80-96;
E-mail: drmuratkara@hotmail.com
page: 25
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RESULTS
by isolating mtDNA of tissues from individuals
with chronic cervicitis and cervix cancer as the
study group and from individuals without any cervical
disease as the control group. In the assessment
of mtDNA obtained from material of 35 patients
with chronic cervicitis, we found heteroplasmy in
28 patients (80.0%) (p = 0.0001). Seven patients
(20.0%) were normal, whereas none of the patients
with chronic cervicitis had the 4977 bp homoplasmic
deletion. The mtDNA assessment of 21 patients
with cervical cancer showed that 17 patients
(81.0%) were normal, two patients (9.5%) had heteroplasmy,
and two patients (9.5%) had the 4977
bp homoplasmic deletion (p = 0.0001). Study of the
mtDNA tissue samples from 16 patients in the control
group showed that fi ve patients had heteroplasmy
(31.2%), 11 individuals were normal (68.8%) (p
= 0.0001). None of the control subjects had a 4977
bp homoplasmic deletion (Table 2 and Figure 1).
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