MITOCHONDRIAL DNA 4977 bp DELETION
IN CHRONIC CERVICITIS AND CERVIX CANCERS
Kara M, Tatar A, Borekci B, Dagli F, Oztas S
*Corresponding Author: Murat Kara M.D., Department of Genetics, School of Medicine, Firat University,
Universite cad. No. 2, 23119 Elazig, Turkey; Tel: +90-424-233-35-55/1938; Fax: +90-424-238-80-96;
E-mail: drmuratkara@hotmail.com
page: 25
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Abstract
Mitochondrial DNA (mtDNA) mutations have
been implied in many diseases including cancer and
infl ammatory diseases. The aim of this study is to investigate
the relationship between the 4977 bp deletion
of the mtDNA and chronic cervicitis or cervix
cancer in patients. The study included a group of patients
with chronic cervicitis or cervix cancer, and a
control group consisting of individuals without any
cervical tissue disease. A total of 72 subjects in an
East Turkish population were included in the study.
Of these, 35 had chronic cervicitis, 21 had cervix
cancer and 16 served as the control group. Isolation
of mtDNA was performed from the tissues of these
patients and then mtDNA deletions were studied using
polymerase chain reaction (PCR). In the cancer
groups, there were 9.5% heteroplasmic and homoplasmic
deletions. There were no homoplasmic deletions
in the cervicitis and control groups, but the
frequencies of heteroplasmic deletions were 80.0 and
31.2%, respectively. Chronic infl ammation leading
to increased reactive oxygen species (ROS) may be
the cause of the high mtDNA 4977 bp deletion frequencies
in cancer and cervicitis. The older age of the
cancer patient may suggest that ageing in addition to
long time exposure to ROS may lead to deletions and
subsequently cancer. This is the fi rst study to investigate
the relationship of the mtDNA 4977 bp deletion
to chronic cervicitis and cervix cancer.
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