PECAM-1 GENE POLYMORPHISM (rs668) AND SUBCLINICAL
MARKERS OF CAROTID ATHEROSCLEROSIS IN PATIENTS
WITH TYPE 2 DIABETES MELLITUS
Popović D, Nikolajević Starčević J, Šantl Letonja M, Makuc J,
Cokan Vujkovac A, Reschner H, Bregar D, Petrovič D
*Corresponding Author: Professor Daniel Petrovič, M.D., Ph.D., Institute of Histology and Embryology,
Faculty of Medicine University Ljubljana, Korytkova 2, SI-1000 Ljubljana, Slovenia. Tel: +386-1-543-7367.
Fax: +386-1-543-7361. E-mail: daniel.petrovic@mf.uni-lj.si
page: 63
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Abstract
The platelet endothelial cell adhesion molecule 1
(PECAM-1) plays an important role in many inflammatory
processes, including the development of atherosclerosis.
Polymorphism rs668 of the PECAM-1
gene (373C/G) is functional, and it was reported to be
associated with increased serum levels of PECAM-1.
We investigated the association between the rs668
polymorphism of PECAM-1 and subclinical markers
of carotid atherosclerosis in subjects with type 2
diabetes mellitus (T2DM). Five hundred and ninetyfive
T2DM subjects and 200 control subjects were
enrolled. The carotid intima-media thickness (CIMT)
and plaque characteristics (presence and structure)
were assessed ultrasonographically. Biochemical
analyses were performed using standard biochemical
methods. Geno-typing of the PECAM-1 gene polymorphism
(rs668) was performed using KASPar assays.
The control examinations were performed 3.8 ±
0.5 years after the initial examination. Higher CIMT
was found in patients with T2DM in comparison with
subjects without T2DM. Statistically sig-nificantly
faster progression of the atherosclerotic markers was
shown in subjects with T2DM in comparison with
the control group. When adjusted to other risk factors,
the rs668 GG genotype was associated with an
increased risk of carotid plaques in subjects with
T2DM. We concluded that our study demonstrated
a minor effect of the rs668 PECAM-1 on markers of
carotid atherosclerosis in subjects with T2DM.
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