ASSOCIATIONS BETWEEN VARIATIONS IN TPH1, TPH2
AND SLC6A4 GENES AND POSTPARTUM DEPRESSION:
A STUDY IN THE JORDANIAN POPULATION
Khabour OF1, Amarneh BH2, Bani Hani EA3, Lataifeh IM4
*Corresponding Author: Dr. Omar F. Khabour, Associate Professor of Molecular Genetics, Department of Medical
Laboratory, Sciences, Jordan University of Science and Technology, PO Box 3030, Irbid 22110, Jordan; Tel.:
+962-2-720-1000 ext. 23784; Fax: +962-2-720-1087; E-mail: khabour@just.edu.jo
page: 41
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Abstract
In this study, we investigated the association between
tryptophan hydroxylase-1 (TPH1) (218A>C),
tryptophan hydroxylase-2 (TPH2) (1463G>A) and
serotonin carrier family 6, member 4 (SLC6A4) [long
(L) vs. short (S)] gene polymorphisms with postpartum
depression (PPD) in women from Jordan.
A total of 370 postpartum (130 depressed and 240
non depressed) women volunteered for the study.
Genotyping was carried out using restriction fragment
length polymorphism (RFLP) for TPH1, amplification
refractory mutation system (ARMS) for
TPH2 and polymerase chain reaction (PCR) for
SLC6A4 S and L. The Edinburgh postnatal depression
scale was used to screen postpartum women. Both S
and L alleles of SLC6A4 are common in Jordanian
women (about 51.0 and 49.0%, respectively), while
allele TPH1-218C is more common (64.0%) than
allele A (37.0%). Regarding TPH2, allele A is absent
from the examined women. None of the examined
polymorphisms were found to be associated with
PPD (p >0.05). However, depression history, pregnancy
problems and economic status were found to
be significantly associated with PPD (p <0.05). The
results suggest that TPH1, TPH2 and SLC6A4 S and
L polymorphisms do not seem to be important in
Jordan for predisposing to PPD.
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