Y CHROMOSOMAL STR LOCUS DYS385 IN AZOOSPERMIC AND FERTILE MEN FROM THE AEGEAN REGION OF TURKEY: IS THERE ANY FORENSIC RELEVANCE?
Unuvar D1, Baransel Isir A2, Cankus G3, Pehlivan S3,*
*Corresponding Author: Associate Professor Sacide Pehlivan, Department of Medical Biology and Genetics, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey; Tel./Fax: +90-34- 2360-6028; e-mail: spehlivan@ gantep.edu.tr; aybaransel@yahoo.com
page: 39

INTRODUCTION

The Y chromosome DNA polymorphism is a male-specific genetic marker. The Y chromosome contains a record of all the mutational events that occurred in a man’s ancestors, reflecting the history of this paternal lineage. Thus, this makes Y chromosome polymorphisms very useful at different levels, including the study of population history and forensic analysis [1-3]. These polymorphisms include small and large scale rearrangements, such as insertions, deletions, duplications and inversions; and those associated with tandemly repeated DNA sequences ranging from large satellite loci to mini- and microsatellites [4].

      Studies of Y chromosome short tandem repeats (STRs) have become increasingly important because of their usefulness in forensic and population genetics [4-6]. In forensic cases, Y-linked STRs are particularly useful for the identification of human remains as well as in rape cases with mixed male-female stain samples [7]. One of the evident applications of the Y chromosome STR analysis is in rapes committed by azoospermic individuals [6,8].

      Recently, a large number of Y-linked STR loci have been characterized as two fragments of variable sizes obtained using a single primer pair. One of these loci, DYS385, which is a highly polymorphic system, has recently been characterized in more detail regarding repeat structure as well as variability in different populations [8,9]. The DYS385 locus consists of two linked STR sub­loci that includes a uniform 4 bp repeat structure, GAAA (10). These two alleles of variable sizes are obtained when this locus is amplified through polymerase chain reaction (PCR) by using one primer pair, and it is regarded as a single haplotype. Therefore, haplotype analysis of the DYS385 locus is expected to provide powerful information for forensic casework [9,11,12]. In this study, we aim to report the distribution of DYS385 genotypes of 49 unrelated azoospermic and 51 fertile males from the Aegean Region of Turkey, and to arrive at a conclusion as to whether or not the DYS385 is a highly polymorphic STR system for population of the Aegean Region of Turkey.

 




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