THERE IS NO ASSOCIATION BETWEEN THE –318 (C→T) AND +49 (A→G)
CTLA4 GENE POLYMORPHISMS AND THE COELIAC CONDITION
IN THE MALTESE POPULATION
Borg J1,*, Scerri CA1,3, Vidal C2, Xuereb Anastasi A1,2
*Corresponding Author: Joseph Borg, B.Sc (Hons) MLS, Laboratory of Molecular Genetics, Department of Physiology and Biochemistry, Biomedical Science Building, University of Malta, Msida, Malta; Tel.: +356-2340-2774, Fax: +356-2134-3535, E-mail: joseph.borg@biotech.um.edu.mt
page: 49
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CONCLUSIONS
Within the Maltese population, the CTLA4 –318 C and +49 A alleles are in linkage disequilibrium and there is no association between the CTLA4 –318 (C→T) and +49 (A→G) SNPs and CD. This could be due to various factors, including founder effects within the Maltese population, as well as the heterogeneous pathogenesis of CD.
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