INVESTIGATION OF THE RELATIONSHIP OF TNFRSF11A
GENE POLYMORPHISMS WITH BREAST CANCER
DEVELOPMENT AND METASTASIS RISK IN PATIENTS
WITH BRCA1 OR BRCA2 PATHOGENIC VARIANTS
LIVING IN THE TRAKYA REGION OF TURKEY
Özdemir K, Gürkan H, Demir S, Atli E, Özen Y, Sezer A, Tunçbilek N, Çicin İ
*Corresponding Author: Hakan Gürkan, MD, PhD, Department of Medical Genetics, Genetic Diseases
Diagnosis Center, Trakya University Faculty of Medicine, Balkan Campus, 22030 Edirne, Turkey. Tel:
+90-533-218-8005. Fax: +90-284-235-7641. Email: dr_hakangurkan@yahoo.de, hgurkan@trakya.edu.tr
page: 49
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CONCLUSIONS
In our study, we investigated the effects of rs4485469,
rs9646629, rs34739845, rs17069904, rs884205 and
rs4941129 SNPs in the TNFRSF11A gene on the risk of
developing breast cancer among patients with BRCA1
and/or BRCA2 variations living in the Trakya region of
Turkey. Among the TNFRSF11A polymorphisms that we
included in our study, the rs4485469 SNP was found to
be significantly borderline between the patient group with
and without BRCA1 or BRCA2 mutations.
Differences in genetic study results related to the
role of TNFRSF11A SNPs in the development process of
breast cancer may be due to ethnic differences between
populations, the inclusion criteria of the patients, and the
different sample numbers. Thus, we suggest that the relationship
between TNFRSF11A polymorphisms and the
risk of breast cancer development by increasing the sample
size and studying in different populations with a similar
methodology will make a significant contribution to the
literature.
Acknowledgments. This study was externally peerreviewed.
Author’s contributions: H. Gürkan conceived
the study; H. Gürkan and K. Özdemir designed the study;
K. Özdemir and Y. Özen were responsible for resources;
A. Sezer and İ. Çicin were responsible for the materials;
H. Gürkan, K. Özdemir, S. Demir and N. Tunçbilek collected
the data and/or processing; H. Gürkan, K. Özdemir,
S. Demir and E. Atli analyzed and interpreted the data; H.
Gürkan, K. Özdemir and S. Demir reviewed the literature;
H. Gürkan, S. Demir, A. Sezer, İ. Çicin and N. Tunçbilek
wrote the manuscript.
Declaration of Interest. The authors report no conflicts
of interest. The authors alone are responsible for the
content and writing of this article.
Funding. This study was funded by the Trakya University
Scientific Research Projects Unit [TÜBAP-2016-252].
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