ASSOCIATIONS BETWEEN VASPIN RS2236242 GENE POLYMORPHISM, WALKING TIME AND THE RISK OF METABOLIC SYNDROME
Suliga E1, Kozieł D2, Cieśla E3, Rębak D2, Wawszczak M2,*, Adamus-Białek W2, Naszydłowska E4, Piechowska A2, Głuszek S2
*Corresponding Author: Monika Wawszczak, MSc, Department of Surgery and Surgical Nursery with Genetics and Research Laboratory, Institute of Medical Sciences, Jan Kochanowski University, al. IX Wieków Kielc 19a, 25-516, Kielce, Poland. Tel: +48-413696978. E-mail: mwawszczak@ujk.edu.pl
page: 41

INTRODUCTION

Vaspin (visceral adipose tissue-derived serine protease inhibitor) was isolated for the first time from visceral adipose tissue in Otsuka Long-Evans Tokushima Fatty rats, which comprises an animal model of abdominal obesity, accompanied by type 2 diabetes mellitus (T2DM) [1]. Human vaspin mRNA has been found both in the visceral and in subcutaneous adipose tissue. It is coded by the gene SERPNA12 located on the long arm of chromosome 14 (14q32.13) and consists of five introns and six exons. According to the literature review, there is a positive association between the vaspin concentration in the blood serum and the indicators of obesity, T2DM, polycystic ovary syndrome (PCOS) and coronary artery disease (CAD) [1,2]. Feng et al. [2] after the meta-analysis of the scores of six studies involving 1826 participants, revealed that the vaspin levels were aproximately 0.52 ng/mL higher in obese patients than in controls. However, some studies showed a lack of associations between the level of vaspin and obesity [3,4]. Several researchers suggest that this adipokin increases the insulin sensitivity of adipose tissue in the condition of obesity. The increase of vaspin expression acts like a compensatory mechanism and being a reaction to growing obesity and insulin resistance. Several studies have revealed that vaspin concentration is related to a better metabolic profile and that its levels in the blood serum are significantly higher in individuals with metabolic syndrome (MetS) than in control [5,6]. So far, only a few studies devoted to the analysis of the relationships between vaspin gene polymorphism and the risk of MetS have been published [6-8]. Studies conducted by Hashemi et al. [7] and Mehanna et al. [8] confirmed that the risk of MetS was significantly lower in allele A rs2236242 carriers. On the other hand, Alnory et al. [6] in the studies involving the Egyptian population, did not find any differences between the frequency of vaspin rs2236242 genotypes and the risk of MetS. Therefore, it was stated that there are only a few studies concerning association between vaspin gene polymorphism and MetS, and their results are ambiguous. No such study has been conducted in the Polish population. According to our current knowledge, none of the previously published studies considered relationship between vaspin rs2236242 polymorphism and the risk of MetS including physical activity or walking. Therefore, the aim of the study was the analysis of the associations between vaspin rs2236242 polymorphism and physical activity in relation to MetS and its components.



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