Balkan Journal of Medical Genetics

FAMILY HISTORY AS AN IMPORTANT FACTOR FOR STRATIFYING PARTICIPANTS IN GENETIC STUDIES OF MAJOR DEPRESSION
Zalar B, Blatnik A, Maver A, Klemenc-Ketiš Z, Peterlin B
*Corresponding Author: Professor Borut Peterlin, Clinical Institute of Medical Genetics, Division of Obstetrics and Gynecology, University Medical Center Ljubljana, Šlajmerjeva 3, 1000 Ljubljana, Slovenia. Tel: +386-1-5401-137. E-mail: borut.peterlin@guest.arnes.si
page: 5

RESULTS

Genotype distributions for tested SNPs in control samples adhered to the Hardy-Weinberg equilibrium. No significant difference in distribution was detected when comparing the MDD cases and healthy controls for any of the variants tested. There were no significant differences using the dominant, recessive or codominant model (data not shown). Genotype and allele distributions for the three tested variants in 133 patients with MDD and 279 healthy controls are shown in Table 1. A comparison of the genotype and allele frequency distributions was also performed between the group of MDD patients with a positive family history for depression and patients with no such family history. A significant difference in genotype and allele frequencies was detected between the two groups of patients for the PCLO rs2522833 polymorphism. The association remained significant even after correction for multiple testing; no other association reached the threshold of statistical significance. Both patients with a positive family history and those with a negative family history were also compared to healthy controls. A significant difference in the allele and genotype frequencies was detected between the familial cases and controls, again for the PCLO rs2522833 polymorphism. The results are shown in Table 2.

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