Balkan Journal of Medical Genetics

MOLECULAR AND IMMUNOHISTOCHEMICAL CHARACTERISTICS OF COMPLETE HYDATIDIFORM MOLES
Kubelka-Sabit KB1,*, Prodanova I2, Jasar D1, Bozinovski G3, Filipovski V1, Drakulevski S1, Plaseska-Karanfilska D3
*Corresponding Author: Dr. Katerina B. Kubelka-Sabit, Clinical Hospital Acibadem Sistina, Skupi 5a, 1000 Skopje, Republic of Macedonia. Tel: +389-70-365-338. Fax: +389-23-099-599. E-mail: catkubelka@ yahoo.co.uk; katerina.kubelka@acibademsistina.mk
page: 27

REFERENCES

1. Hui P, Baergen R, Cheung ANY, Fukunaga M, Gersell D, Lage JM, et al. Gestational trophoblastic disease. In: Kurman RJ, Carcangiu ML, Herrington CS, Young RH, Eds. WHO Classification of Tumours of Female Reproductive Organs, 4th ed. Lyon, France: IARC Press. 2014: 155-168. 2. Erfanian M, Sharifi N, Omidi AA. P63 and Ki-67 expression in trophoblastic disease and spontaneous abortion. J Res Med Sci. 2009; 14(6): 375-384. 3. Fernández J, Cortes R, Salazar A, Pulido A, Dabed B, Garcia V. p57 kip2 immunohistochemistry: Ancillary technique in hydatidiform moles diagnosis. BMC Proceedings. 2013; 7(2): P33. 4. Golfier F, Clerc J, Hajri T, Massardier J, Frappart L, Duvillard P, et al. Contribution of referent pathologists to the quality of trophoblastic diseases diagnosis. Hum Reprod. 2011; 26(10): 2651-2657. 5. Sundvall L, Lund H, Niemann I, Jensen UB, Bolund L, Sunde L. Tetraploidy in hydatidiform moles. Hum Reprod. 2013; 28(7): 2010-2020. 6. Heidarpour M, Khanahmadi M. Diagnostic value of P63 in differentiating normal gestation from molar pregnancy. J Res Med Sci. 2013; 18(6): 462-466. 7. Carey L, Nash BM, Wright DC. Molecular genetic studies of complete hydatidiform moles. Transl Pediatr. 2015; 4(2): 181-188. 8. Kipp BR, Ketterling RP, Oberg TN, Cousin MA, Plagge AM, Wiktor AE, et al. Comparison of fluorescence in situ hybridization, p57 immunostaining, flow cytometry, and digital image analysis for diagnosing molar and nonmolar products of conception. Am J Clin Pathol. 2010; 133(2): 196-204. 9. Landolsi H, Missaoui N, Yacoubi MT, Trabelsi A, Rammeh-Rommani S, Hidar S, et al. Assessment of the role of histopathology and DNA image analysis in the diagnosis of molar and non-molar abortion: a study of 89 cases in the center of Tunisia. Pathol Res Pract. 2009; 205(11): 789-796. 10. Sarmadi S, Izadi-Mood N, Abbasi A, Sanii S. p57KIP2 immunohistochemical expression: A useful diagnostic tool in discrimination between complete hydatidiform mole and its mimics. Arch Gynecol Obstet. 2011; 283(4): 743-748. 11. Niemann I, Petersen LK, Hansen ES, Sunde L. Differences in current clinical features of diploid and triploid hydatidiform mole. BJOG. 2007; 114(10): 1273-1277. 12. Fukunaga M. Immunohistochemical characterization of p57Kip2 expression in tetraploid hydropic placentas. Arch Pathol Lab Med. 2004; 28(8): 897-900. 13. Bewtra C, Frankforter S, Marcus JN. Clinicopathologic differences between diploid and tetraploid complete hydatidiform moles. Int J Gynecol Pathol. 1997; 16(3): 239-244. 14. Candelier JJ. [Complete hydatidiform mole]. Med Sci (Paris). 2015; 31(10): 861-868. 15. Chen, CP, Ko TM, Chen CY, Wang TY, Chern SR, Kuo YL, et al. First-trimester molecular diagnosis of complete hydatidiform mole associated with dizygotic twin pregnancy conceived by intrauterine insemination. Taiwan J Obstet Gynecol. 2014; 53(4): 572-578. 16. Niemann I, Sunde L, Petersen LK. Evaluation of the risk of persistent trophoblastic disease after twin pregnancy with diploid hydatidiform mole and coexisting normal fetus. Am J Obstet Gynecol. 2007; 197(1): 45.e1-e5. 17. Paul M, Goodman S, Felix J, Lewis R, Hawkins M, Drey E. Early molar pregnancy: Experience in a large abortion service. Contraception. 2010; 81(2): 150-156. 18. Banet N, DeScipio C, Murphy K, Beierl K, Adams E, Vang R, et al. Characteristics of hydatidiform moles: Analysis of a prospective series with p57 immunohistochemical and molecular genotyping. Mod Pathol. 2014; 27(2): 238-254. 19. Sasaki S, Sasaki Y, Kunimura T, Sekozawa A, Kojima Y, Iino K. Clinical Usefulness of immunohistochemical staining of p57 kip2 for the differential diagnosis of complete mole. Biomed Res Int. 2015; 2015: 905648. 20. Fisher RA, Hodges MD, Rees HC, Sebire NJ, Seckl MJ, Newlands ES, et al. The maternally transcribed gene p57(KIP2) (CDNK1C) is abnormally expressed in both androgenetic and biparental complete hydatidiform moles. Hum Mol Genet. 2002; 11(26): 3267-3272. 21. Ramalho LN, Maggiori MS, Ribeiro-Silva A, Peres LC. P63 expression in hydropic abortion and gestational trophoblastic diseases. Placenta. 2006; 27(6-7): 740-743. 22. Hemida R, van Doorn H, Fisher R. A novel genetic mutation in a patient with recurrent biparental complete hydatidiform mole: A brief report. Int J Gynecol Cancer. 2016; 26(7): 1351-1353. 23. Parry DA, Logan CV, Hayward BE, Shires M, Landolsi H, Diggle C, et al. Mutations causing familial biparental hydatidiform mole implicate c6orf221 as a possible regulator of genomic imprinting in the human oocyte. Am J Hum Genet. 2011; 89(3): 451-458. 24. Murdoch S, Djuric U, Mazhar B, Seoud M, Khan R, Kuick R, et al. Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans. Nat Genet. 2006; 38(3): 300-302. 25. Hayward BE, De Vos M, Talati N, Abdollahi MR, Taylor GR, Meyer E, et al. Genetic and epigenetic analysis of recurrent hydatidiform mole. Hum Mutat. 2009; 30(5): E629-E639. 26. Akoury E, Gupta N, Bagga R, Brown S, Dery C, Kabra M, et al. Live births in women with recurrent hyda-tidiform mole and two NLRP7 mutations. Reprod Biomed Online. 2015; 31(1): 120-124. 27. Reubinoff BE, Lewin A, Verner M, Safran A, Schenker JG, Abeliovich D. Intracytoplasmic sperm injection combined with preimplantation genetic diagnosis for the prevention of recurrent gestational trophoblastic disease. Hum Reprod. 1997; 12(4): 805-808. 28. Fisher RA, Khatoon R, Paradinas FJ, Roperts AP, Newlands ES. Repetitive complete hydatidiform mole can be biparental in origin and either male or female. Hum Reprod. 2000; 15(3): 594-598. 29. Eagles N, Sebire NJ, Short D, Savage PM, Seckl MJ, Fisher RA. Risk of recurrent molar pregnancies following complete and partial hydatidiform moles. Hum Reprod. 2015; 30(9): 2055-2063. 30. Sebire NJ, Fisher RA, Foskett M, Rees H, Seckl MJ, Newlands ES. Risk of recurrent hydatidiform mole and subsequent pregnancy outcome following complete or partial hydatidiform molar pregnancy. BJOG. 2003; 110(1): 22-26. 31. Petts G, Fisher RA, Short D, Linday I, Seckl ML, Sebire NJ. Histopathological and immunohistochemical features of early hydatidiform mole in relation to subsequent development of persistent gestational trophoblastic disease. J Reprod Med. 2014; 59(5-6): 213-220.

Number 27 VOL. 27 (2), 2024	Number 27 VOL. 27 (1), 2024
Number 26 Number 26 VOL. 26(2), 2023 All in one	Number 26 VOL. 26(2), 2023
Number 26 VOL. 26, 2023 Supplement	Number 26 VOL. 26(1), 2023
Number 25 VOL. 25(2), 2022	Number 25 VOL. 25 (1), 2022
Number 24 VOL. 24(2), 2021	Number 24 VOL. 24(1), 2021
Number 23 VOL. 23(2), 2020	Number 22 VOL. 22(2), 2019
Number 22 VOL. 22(1), 2019	Number 22 VOL. 22, 2019 Supplement
Number 21 VOL. 21(2), 2018	Number 21 VOL. 21 (1), 2018
Number 21 VOL. 21, 2018 Supplement	Number 20 VOL. 20 (2), 2017
Number 20 VOL. 20 (1), 2017	Number 19 VOL. 19 (2), 2016
Number 19 VOL. 19 (1), 2016	Number 18 VOL. 18 (2), 2015
Number 18 VOL. 18 (1), 2015	Number 17 VOL. 17 (2), 2014
Number 17 VOL. 17 (1), 2014	Number 16 VOL. 16 (2), 2013
Number 16 VOL. 16 (1), 2013	Number 15 VOL. 15 (2), 2012
Number 15 VOL. 15, 2012 Supplement	Number 15 Vol. 15 (1), 2012
Number 14 14 - Vol. 14 (2), 2011	Number 14 The 9th Balkan Congress of Medical Genetics
Number 14 14 - Vol. 14 (1), 2011	Number 13 Vol. 13 (2), 2010
Number 13 Vol.13 (1), 2010	Number 12 Vol.12 (2), 2009
Number 12 Vol.12 (1), 2009	Number 11 Vol.11 (2),2008
Number 11 Vol.11 (1),2008	Number 10 Vol.10 (2), 2007
Number 10 10 (1),2007	Number 9 1&2, 2006
Number 9 3&4, 2006	Number 8 1&2, 2005
Number 8 3&4, 2004	Number 7 1&2, 2004
Number 6 3&4, 2003	Number 6 1&2, 2003
Number 5 3&4, 2002	Number 5 1&2, 2002
Number 4 Vol.3 (4), 2000	Number 4 Vol.2 (4), 1999
Number 4 Vol.1 (4), 1998	Number 4 3&4, 2001
Number 4 1&2, 2001	Number 3 Vol.3 (3), 2000
Number 3 Vol.2 (3), 1999	Number 3 Vol.1 (3), 1998
Number 2 Vol.3(2), 2000	Number 2 Vol.1 (2), 1998
Number 2 Vol.2 (2), 1999	Number 1 Vol.3 (1), 2000
Number 1 Vol.2 (1), 1999	Number 1 Vol.1 (1), 1998

About the journal ::: Editorial ::: Subscription ::: Information for authors ::: Contact