
POLYMORPHISM OF THE IL13 GENE MAY BE
ASSOCIATED WITH UTERINE LEIOMYOMAS
IN SLOVENIAN WOMEN Krsteski J, Jurgec S, Pakiž M, But I, Potočnik U, *Corresponding Author: Professor Uroš Potočnik, Ph.D., Centre for Human Molecular Genetics and Pharmacogenomics,
Faculty of Medicine, University of Maribor, Taborska Ulica 8, 2000 Maribor, Slovenia. Tel: +386-2-2345-854, Fax: +386-2-
2345-820, E-mail: uros.potocnik@um.si page: 51
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REFERENCES
1. Wallach EE, Vlahos NF. Uterine myomas: An overview
of development, clinical features, and management.
Obstet Gynecol. 2004; 104(2): 393-406.
2. Cramer SF, Patel A. The frequency of uterine leiomyomas.
Am J Clin Pathol. 1990; 94(4): 435-438.
3. Marsh EE, Bulun SE. Steroid hormones and leio-myomas.
Obstet Gynecol Clin North Am. 2006; 33(1):
59-67.
4. Walker CL, Stewart EA. Uterine fibroids: The elephant
in the room. Science. 2005; 308(5728): 1589-1592.
5. Sandberg AA. Updates on the cytogenetics and molecular
genetics of bone and soft tissue tumors: Leiomyoma.
Cancer Genet Cytogenet. 2005; 158(1): 1-26.
6. Flake GP, Andersen J, Dixon D. Etiology and pathogenesis
of uterine leiomyomas: A review. Environ
Health Perspect. 2003; 111(8): 1037-1054.
7. Paltridge JL, Belle L, Khew-Goodall Y. The secretome
in cancer progression. Biochim Biophys Acta.
2013; 1834(11): 2233-2241.
8. Li S, Jin T, Zhang J, Lou H, Yang B, Li Y, et al.
Polymorphisms of TREH, IL4R and CCDC26 genes
associated with risk of glioma. Cancer Epidemiol.
2012; 36(3): 283-287.
9. Yuan LJ, Jin TB, Yin JK, Du XL, Wang Q, Dong R,
et al. Polymorphisms of tumor-related genes IL-10,
PSCA, MTRR and NOC3L are associated with the
risk of gastric cancer in the Chinese Han population.
Cancer Epidemiol. 2012; 36(6): e366-e372.
10. Islam MS, Protic O, Stortoni P, Grechi G, Lamanna
P, Petraglia F, et al. Complex networks of multiple
factors in the pathogenesis of uterine leiomyoma.
Fertil Steril. 2013; 100(1): 178-193.
11. Malyshkina AI, Posiseeva LV, Sotnikova NY, Antsiferova
JS, Suvorkina EE, Arevadze IE. Local immunological
markers of different rate of growth of
uterine myoma. Russ J Immunol. 2002; 7(1): 58-62.
12. Sano M, Inoue S, Hosoi T, Ouchi Y, Emi M, Shiraki
M, et al. Association of estrogen receptor dinucleotide
repeat polymorphism with osteoporosis. Biochem
Biophys Res Commun. 1995; 217(1): 378-383.
13. Hsieh YY, Chang CC, Tsai CH, Lin CC, Tsai FJ. Interleukin
(IL)-12 receptor β1 codon 378 G homozygote
and allele, but not IL-1 (β511 promoter, 3953 exon
5, receptor antagonist), IL-2 114, IL-4-590 intron 3,
IL-8 3’-UTR 2767, and IL-18 105, are associated
with higher susceptibility to leiomyoma. Fertil Steril.
2007; 87(4): 886-895.
14. Sosna O, Kolesár L, Slavčev A, Skibová J, Fait T,
Mara M, et al. Th1/Th2 cytokine gene polymorphisms
in patients with uterine fibroid. Folia Biol
(Praha). 2010; 56(5): 206-210.
15. Pietrowski D, Thewes R, Sator M, Denschlag D, Keck
C, Tempfer C. Uterine leiomyoma is associated with
a polymorphism in the interleukin 1-β gene. Am J
Reprod Immunol. 2009; 62(2): 112-127.
16. Taghizade-Mortezaee F, Hashemzadeh-Chaleshtori
M, Kheiri S, Parvin N, Norbakhsh M, Etemadi S, et
al. Association of interleukin-1β (IL-1β) gene polymorphisms
with uterine leiomyoma. Zahedan J Res
Med Sci. 2012; 14(7): 53-56.
17. Pakiz M, Potocnik U, But I. Solitary and multiple uterine
leiomyomas among Caucasian women: Two different
disorders? Fertil Steril. 2010; 94(6): 2291-2295.
18. Shao R, Fang L, Xing R, Xiong Y, Wang Z. Differential
expression of estrogen receptor α and β isoforms
in multiple and solitary leiomyomas. Biochem Biophys
Res Commun. 2015; 468(1-2): 136-142.
19. Burkholder B, Huang RY, Burgess R, Luo S, Jones
VS, Zhang W, et al. Tumor-induced perturbations
of cytokines and immune cell networks. Biochim
Biophys Acta. 2014; 1845(2): 182-201.
20. Cabantous S, Ranque S, Poudiougou B, Traore A,
Berbache S, Vitte J, et al. Genotype combinations
of two IL4 polymorphisms influencing IL-4 plasma
levels are associated with different risks of severe
malaria in the Malian population. Immunogenetics.
2015; 67(5-6): 283-288.
21. Mitsuyasu H, Izuhara K, Mao XQ, Gao PS, Arinobu
Y, Enomoto T, et al. Ile50Val variant of IL4R α upregulates
IgE synthesis and associates with atopic
asthma. Nat Genet. 1998; 19(2): 119-120.
22. Xiao JP, Wang XR, Zhang S, Wang HY, Ye L, Pan HF,
et al. Association between rs6887695 and 3’-untranslated
region polymorphisms within the interleukin-
12B gene and susceptibility to autoimmune diseases
in Asian and European population: A meta-analysis.
Autoimmunity. 2016; 49(4): 277-284.
23. Jin T, Li X, Zhang J, Wang H, Geng T, Li G, et al. Genetic
association between selected cytokine genes and
glioblastoma in the Han Chinese population. BMC
Cancer. 2013; 13: 236.
24. Hussain SK, Madeleine MM, Johnson LG, Du Q,
Galloway DA, Daling JR, et al. Nucleotide variation
in IL-10 and IL-12 and their receptors and cervical
and vulvar cancer risk: A hybrid case-parent triad
and case-control study. Int J Cancer. 2013; 133(1):
201-213.
25. Perneger TV. What’s wrong with Bonferroni adjustments.
BMJ. 1998;316(7139):1236-1238.
26. Chu H, Wang M, Yan F, Zhong D, Shi D, Ma L, et
al. Polymorphisms in the IL-13 and IL-4R genes are
associated with the development of renal cell carcinoma.
Ann Oncol. 2012; 23(8): 2114-2121.
27. Chu H, Ma L, Wang M, Shi D, Qin C, Yuan L, et al.
The polymorphisms of IL-4, IL-4R and IL-13 genes
and bladder cancer risk in a Chinese population: A casecontrol
study. Mol Biol Rep. 2012; 39(5): 5349-5357.
28. Graves PE, Kabesch M, Halonen M, Holberg CJ,
Baldini M, Fritzsch C, et al. A cluster of seven tightly
linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of
white children. J Allergy Clin Immunol. 2000; 105(3):
506-513.
29. Schoemaker MJ, Swerdlow AJ, Hepworth SJ, van
Tongeren M, Muir KR, McKinney PA. History of
allergic disease and risk of meningioma. Am J Epidemiol.
2007; 165(5): 477-485.
30. Biggar RJ, Christiansen M, Rostgaard K, Smedby KE,
Adami HO, Glimelius B, et al. Immunoglobulin subclass
levels in patients with non-Hodgkin lymphoma.
Int J Cancer. 2009; 124(11): 2616-2620.
31. van Toorenenbergen AW, van Heerde MJ, van Buuren
HR. Potential value of serum total IgE for differentiation
between autoimmune pancreatitis and pancreatic
cancer. Scand J Immunol. 2010; 72(5): 444-448.
32. van der Pouw Kraan TC, van der Zee JS, Boeije LC,
de Groot ER, Stapel SO, Aarden LA. The role of IL-
13 in IgE synthesis by allergic asthma patients. Clin
Exp Immunol. 1998; 111(1): 129-135.
33. Luo X, Ding L, Xu J, Chegini N. Gene expression profiling
of leiomyoma and myometrial smooth muscle
cells in response to transforming growth factor-β.
Endocrinology. 2005; 146(3): 1097-1118.
34. Kurachi O, Matsuo H, Samoto T, Maruo T. Tumor
necrosis factor-α expression in human uterine leiomyoma
and its down-regulation by progesterone. J
Clin Endocrinol Metab. 2001; 86(5): 2275-2280.
35. McCawley LJ, Matrisian LM. Matrix metalloproteinases:
They’re not just for matrix anymore! Curr Opin
Cell Biol. 2001; 13(5): 534-540.
36. Wynn TA. IL-13 effector functions. Annu Rev Immunol.
2003; 21: 425-456.
37. Terabe M, Matsui S, Noben-Trauth N, Chen H, Watson
C, Donaldson DD, et al. NKT cell-mediated repression
of tumor immunosurveillance by IL-13 and
the IL-4R-STAT6 pathway. Nat Immunol. 2000; 1(6):
515-520.
38. Berzofsky JA, Terabe M. A novel immunoregulatory
axis of NKT cell subsets regulating tumor immunity.
Cancer Immunol Immunother. 2008; 57(11): 1679-
1683.
39. Zimmermann A, Bernuit D, Gerlinger C, Schaefers
M, Geppert K. Prevalence, symptoms and management
of uterine fibroids: An international internetbased
survey of 21,746 women. BMC Womens
Health. 2012; 12): 6.
40. Kobayashi M, Kobayashi H, Pollard RB, Suzuki F.
A pathogenic role of Th2 cells and their cytokine
products on the pulmonary metastasis of murine B16
melanoma. J Immunol. 1998; 160(12): 5869-5873.
41. Day FR, Helgason H, Chasman DI, Rose LM, Loh
PR, Scott RA, et al. Physical and neurobehavioral
determinants of reproductive onset and success. Nat
Genet. 2016; 48(6): 617-623.
42. Pandis N, Karaiskos C, Bardi G, Sfikas K, Tserkezoglou
A, Fotiou S, et al. Chromosome analysis of
uterine adenomyosis. Detection of the leiomyomaassociated
del(7q) in three cases. Cancer Genet Cytogenet.
1995; 80(2): 118-120.
43. van Voorhis BJ, Romitti PA, Jones MP. Family history
as a risk factor for development of uterine leiomyomas.
Results of a pilot study. J Reprod Med. 2002;
47(8): 663-669.
44. Marshall LM, Spiegelman D, Goldman MB, Manson
JE, Colditz GA, Barbieri RL, et al. A prospective
study of reproductive factors and oral contraceptive
use in relation to the risk of uterine leiomyomata.
Fertil Steril. 1998; 70(3): 432-439.
45. Moravek MB, Bulun SE. Endocrinology of uterine
fibroids: Steroid hormones, stem cells, and genetic
contribution. Curr Opin Obstet Gynecol. 2015; 27(4):
276-283.
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