Balkan Journal of Medical Genetics

INVESTIGATION OF THE N-TERMINAL CODING REGION OF MUC7 ALTERATIONS IN DENTISTRY STUDENTS WITH AND WITHOUT CARIES
Koç Öztürk L, Yarat A, Akyuz S, Furuncuoglu H, Ulucan K,
*Corresponding Author: Dr. Korkut Ulucan, Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Üsküdar University, Haluk Turksoy Sok. No. 14, Üsküdar, İstanbul 34662, Turkey. Tel: +90-216-400-2222-2409. Fax: +90-216-400-2222; Mobile: +90-532-692-1922. E-Mail: korkutulucan@hotmail.com
page: 71

INTRODUCTION

Dental caries is one of the most prevalent human infectious diseases affecting life style and genetic factors. The skewed distribution of caries in the Western populations and its weak association with traditional life style factors, e.g., sugar intake and oral hygiene, suggest genetic components in caries development. Early studies have shown that there were large individual differences in caries development in spite of similar exposures to sugars [1]. Mucins are vital components of the mucous layers covering the epithelial surfaces of the human body. In the oral cavity, mucins are secreted by submandibular and sublingual glands, and various minor salivary glands, but not by the parotid glands. Mucins constitute the third most abundant group of proteins in saliva and form various complexes with other salivary proteins, thereby modulating their activities. Two structurally distinct mucins have been identified in human saliva: high-molecular weight (MG1) and the low-molecular weight (MG2) mucins [2]. The human MUC7 gene encodes a relatively small mucin glycoprotein, MUC7 (125 kD). It is also known as MG2. Low-molecular weight mucin is secreted mainly by human sublingual and submandibular glands. As a salivary glycoprotein, it is involved in mastication, speech, swallowing and lubrication of the oral cavity [3]. Early studies indicate that MG2 takes part in the human salivary nonimmune defense system and interacts with oral microorganisms, and it also appears that MG2 plays a role in mediating interactions between neutrophils and bacteria. The ability of MG2 to self-associate, creating larger assemblies through non covalent bonds, has also been proposed to contribute to the agglutinating and eliminating properties of the mucin [4]. The exploitation of mucin molecules for diagnostics is gaining increasing interest in a variety of disease conditions [3]. A recent study has suggested that genetic polymorphisms, which can alter mucin gene expression, have been associated with mucinrelated diseases [5]. While no studies have been performed on the MG2 polymorphism for dental caries, the potential of these molecules about dental caries cannot be ignored and will likely be subjected to further exploration. To date, the relationship between the MUC7 N-terminal coding region and dental caries is still unclear. Thus, in the present study, we aim to identify the effects of N-terminal coding region MUC7 polymorphisms and dental caries.

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