Balkan Journal of Medical Genetics

THE LARGEST PARACENTRIC INVERSION, THE HIGHEST RATE OF RECOMBINANT SPERMATOZOA. CASE REPORT: 46,XY, inv(2)(q21.2q37.3) AND LITERATURE REVIEW
Yapan CC, Beyazyurek C, Ekmekci CG, Kahraman S
*Corresponding Author: Cigdem Cinar Yapan, MSc., Reproductive Genetics Laboratory, Istanbul Memorial Hospital, Piyalepasa Street, 34385 Sisli, Istanbul, Turkey. Tel.: +90-212-314-6666. Fax: +90-212-314-6657. E-mail: cigdemcinar78@gmail.com
page: 55

RESULTS

Meiotic segregation analysis of the PAI for chromosome 2 revealed that 378 spermatozoa were abnormal (28.0%) (Figure 3). The rate of normal or balanced (inverted) spermatozoa was 72.0% (Figure 4). The aneuploidy rates for chromosomes 13, 15, 17, 18, 21, and XY were 1.2, 0.92, 8.4, 1.2, 0.9 and 1.5%, respectively (Table 1). As a result of hyperstimulation, five oocytes were picked up, four of them were matured and fertilized after intracytoplasmic sperm injection (ICSI) [20]. Four zygotes were cultured until day 3. Two of these embryos were arrested and the other two were slow-growing embryos. Unfortunately, embryo biopsy and preimplantation genetic diagnosis (PGD) could not be performed due to poor quality of the embryos. Two grade III embryos were transferred on the third day of embryonic growth without genetic analysis. Pregnancy was not achieved in this cycle.

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