LACK OF ASSOCIATION BETWEEN VARIANTS WITHIN THE
AHSG, HCRT AND NPY2R GENES AND ANTHROPOMETRICAL
PARAMETERS IN CZECH POST-MONICA STUDY Jurcikova L*, Adamkova V, Lanska V, Suchanek P, Hubacek JA *Corresponding Author: Ing. Lucie Jurčíková, Institute for Clinical and Experimental Medicine, DEM, Videnska
1958/9, Prague 4, 14021, Czech Republic; Tel.: +420-261-362-229; Fax: +420-241-721-574; E-mail: jurl@ikem.cz page: 63
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DISCUSSION
The hypothesis of variants within the AHSG,
NPY2R and HCRT genes being significant determinants
of plasma lipids or obesity markers in the Czech
population was not confirmed by this large population
study. An association of AHSG concentration with
triglyceride levels has been described [26], which is
consistent with our results. In our large study, we also
demonstrated a possible increase of total cholesterol in
AHSG rs4917 T allele carriers. However, in our study,
we did not confirm any other previous observations
regarding its influence on low density lipo-proteins
(LDL)-cholesterol, central obesity or blood glucose
[27]. No significant impact of the rs4917 polymorphism
on BMI, waist circumference or plasma levels
of glucose was found, which supports the results of a
previous study on Scandinavian women. In contrast
to the Swedish study, where significant association
between the rs4917 polymorphism and plasma cholesterol
was found [3], in our study only triglycerides
were significantly changed.
No significant relationship between rs4917 AHSG
variant and anthropometrical parameters or lipids was
found in an interventional study of 105 unrelated overweight
adult Czech females. However, CC homozygotes
showed an increase of lean muscle mass, decrease
of total body fat and increased basal metabolic
rate per kg of body weight in contrast to T carriers [2].
Although no relationship between the NPY2R
rs1047214 SNP was found in our study, some studies
have described some effects. In Swedish men, the common T allele was associated with lower BMI
[1]. In contrast, another study of selected UK adults
connects the T allele with higher BMI. This could be
explained by the inclusion of morbidly obese and,
consequently, a higher BMI median than in the Swedish
study [23]. This study also shows, apart from BMI,
higher WHR in T allele carriers. Neither triglyceride
nor glucose levels were influenced [1]. In the French
study of NPY2R rs1047214, the T allele was associated
with lower WHR, but not with BMI in boys and
not with adults [21].
Minimum studies have focused on rs760282
HCRT variant. Similar to others [18], we did not find
any association with obesity parameters. In conclusion,
we are not able to confirm that polymorphisms
within the AHSG, HCRT and NPY2R genes are major
genetic determinants of BMI and plasma lipids in the
Czech-Slavonic population.
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