INFLUENCE OF POTENTIAL GENE POLYMORPHISMS
ON PROPOFOL DOSAGE REGIMEN IN PATIENTS
UNDERGOING ABDOMINAL HYSTERECTOMY
Ivanov E, Sterjev Z, Budic I, Nojkov J, Karadzova D, Sivevski A
*Corresponding Author: Emilija Ivanov, Prim. M.Med., University Clinic for Gynecology and Obstetrics,
University “Ss Cyril and Methodius” Medical Faculty, Mother Theresa, Skopje, Republic of North
Macedonia. Tel./Fax: +389-(0)-23-228-440. E-mail: emilijaivanov@gmail.com
page: 41
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Abstract
Propofol (2,6-diisopropylphenol) is the most common
intravenous anesthetic used in modern medicine. It
is postulated that individual differences in genetic factors
[polymorphism of single nucleotide polymorphisms
(SNPs)] in the genes encoding metabolic enzymes, molecular
targets and molecular binding sites of propofol
can be responsible for susceptibility to propofol effects.
The aim of our study was to investigate the influence of
the cytochrome P450 2B6 isozyme CYP2B6 (rs3745274),
γ-aminobutyric acid type A (GABAA) receptor α1 subunit
GABRA1 (rs2279020) and ATP-binding cassette subfamily
B member 1 ABCB1 (rs1045642) gene polymorphisms
on propofol therapeutic outcomes in the patients
undergoing abdominal hysterectomy. Ninety patients aged
29-74 years, with different ethnicities were included in this
study. The presence of polymorphisms was analyzed using
TaqMan SNP genotype analysis on Stratagene MxPro
3005P real-time polymerase chain reaction (qPCR). The
distribution of all three genetic variants was within the
Hardy-Weinberg equilibrium. There was no significant
difference (p >0.05) in the allelic frequencies of polymorphic
variants and genotype distributions between adult and
older patients and between patients of different ethnicities.
Our study did not detect a statistically significant influence
of the CYP2B6 (c.516G>A), GABRA1 (c.1059+15G>A)
and ABCB1 (c.3435T>C) variants on the variability of
clinical parameters (doses for induction in anesthesia, additional
doses, induction time and wake time after anesthesia
and side effects of propofol). However, the observed trend
on the possible influence of the CYP2B6 (c.516G>A) and
GABRA1 (c.1059+15G>A) variants warrant an extension
of these studies on a larger number of patients.
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