Introduction: Infertility has been described as a failure to conceive after at least one year of unprotected intercourse. The incidence of chromosomal abnormalities is 10 to 20 fold higher (2.2-14.3%) in males with infertility compared to general male population (0.7-1%). In this study, we aimed to investigate the contribution of chromosomal aberrations to the male infertility. Material and methods: We reviewed the cytogenetic results of the male patients referred to our department with the diagnosis of infertility in a 6-year period between 2000-2005. Results: We reviewed 127 male patients with infertility. Chromosomal abnormalities were found in 23 cases (18.1%). Conclusion: It is clear that there are lots of genetic factors causing to infertility such as microdeletions of chromosome Y, some mutations of CFTR gene, mutations in SOX9, KALIG1 etc., but cytogenetic examinations should be made prior to molecular studies.