ADRB2 GENE POLYMORPHISMS AND SALBUTAMOL
RESPONSIVENESS IN SERBIAN CHILDREN WITH ASTHMA
Jovicic N, Babic T, Dragicevic S, Nestorovic B, Nikolic A
*Corresponding Author: Dr. Nevena Jovicic, Department of Pulmonology and Allergology, University Children’s Hospital,
Tirsova 10, 11000 Belgrade, Serbia. Tel: +38-164-115-6721. Fax: +38-111-268-5378. E-mail: jovicic.nevena@gmail.com
page: 33
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Abstract
Inhaled β2 adrenergic receptor (β2-AR) agonists are
the mainstay of asthma therapy. The β2-AR protein is encoded
by the ADRB2 gene and variants within this gene can
have significant consequences for modulating the response
to asthma therapy. This cross-sectional study performed at
the University Children’s Hospital in Belgrade, included
54 children with asthma. The subjects were genotyped for
ADRB2 +46A>G (Arg16Gly, rs1042713) and +79C>G
(Gln27Glu, rs1042714) polymorphisms and the association
with asthma severity and response to inhaled salbutamol
was examined. In Serbian asthmatic children, allele +46A
was detected with a frequency of 41.7% and allele +79G
was detected with a frequency of 23.1%. Allele +46G was
found to be associated with a better response to inhaled salbutamol
(p <0.05) and with mild form of asthma (p <0.05).
Polymorphism ADRB2 +46A>G may be a determinant
of asthma severity and response to salbutamol in children
with asthma. We did not find any association of +79C>G
polymorphisms with the asthma severity and bronchodilator
response to inhaled salbutamol. The results of this study can
be potentially useful for personalization of asthma treatment.
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