ASSOCIATION BETWEEN OSTEOPROTEGERIN GENE
POLYMORPHISMS AND RISK OF CORONARY ARTERY
DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS
Jia P, Wu N, Jia D*, Sun Y*
*Corresponding Author: Professor Dalin Jia and/or Professor Yingxian Sun, Department of Cardiology, The First Affiliated
Hospital of China Medical University, 155th North Nanjing Street, Heping District, Shenyang 110001, Liaoning Province,
People’s Republic of China. Tel: +86-242-326-9477. Fax: +86-242-326-9477. Email: jdl2001@126.com and/or
yxsun@mail.cmu.edu.cn
page: 27
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Abstract
Osteoprotegerin (OPG) has been demonstrated to be
a novel biomarker for predicting prevalence and severity
of coronary artery disease (CAD). Furthermore, recent
studies have shown that OPG gene polymorphisms are
associated with a susceptibility to CAD. However, published
studies showed inconsistent results. Therefore, a
meta-analysis of eligible studies reporting the association
between OPG gene polymorphisms and CAD was
carried out. A systematic search was conducted using
PubMed, Web of Science, Cochrane Library, Chinese
National Knowledge Infrastructure (CNKI) and Chinese
Wan Fang databases. Odds ratio (OR) with corresponding
95% confidence interval (95% CI) were calculated. Overall,
six eligible studies were included and four OPG gene
polymorphisms (G209A, T245G, T950C and G1181C)
were further evaluated for the association with susceptibility
to CAD in this meta-analysis. Meta-analysis showed
that G1181C and T950C polymorphisms were strongly
associated with the risk of CAD, but no association existed
between G209A and T245G polymorphisms and
the risk of CAD. In conclusion, our meta-analysis is the
first report to estimate the association between OPG gene
polymorphisms and susceptibility to CAD. Further large
scale case-control studies with rigorous design should be
conducted to confirm the above conclusions in the future.
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