MICROARRAY TECHNOLOGY REVEALS POTENTIALLY
NOVEL GENES AND PATHWAYS INVOLVED IN
NON-FUNCTIONING PITUITARY ADENOMAS Qiao X, Wang H, Wang X, Zhao B, Liu J, *Corresponding Author: Jun Liu, M.D., Department of Neurosurgery, The Second Hospital of Jilin University, 218 Ziqiang
Road, Changchun, 130021, Jilin Province, People’s Republic of China. Tel: +86-138-0431-7080. E-mail: LiuJun66@126.com page: 5 download article in pdf format
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Abstract
Microarray data of non-functioning pituitary adenomas
(NFPAs) were analyzed to disclose novel genes and
pathways involved in NFPA tumorigenesis. Raw microarray
data were downloaded from Gene Expression Omnibus.
Data pre-treatment and differential analysis were
conducted using packages in R. Functional and pathway
enrichment analyses were performed using package GOstats.
A protein-protein interaction (PPI) network was constructed
using server STRING and Cytoscape. Known
genes involved in pituitary adenomas (PAs), were obtained
from the Comparative Toxicogenomics Database. A total
of 604 differentially expressed genes (DEGs) were identified
between NFPAs and controls, including 177 up- and
427 down-regulated genes. Jak-STAT and p53 signaling
pathways were significantly enriched by DEGs. The PPI
network of DEGs was constructed, containing 99 up- and
288 down-regulated known disease genes (e.g. EGFR and
ESR1) as well as 16 up- and 17 down-regulated potential
novel NFPAs-related genes (e.g. COL4A5, LHX3, MSN,
and GHSR). Genes like COL4A5, LHX3, MSN, and GHSR
and pathways such as p53 signaling and Jak-STAT signaling,
might participate in NFPA development. Although further
validations are required, these findings might provide
guidance for future basic and therapy researches.
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