ASSOCIATION OF THE ACE rs4646994 AND rs4341
POLYMORPHISMS WITH THE PROGRESSION
OF CAROTID ATHEROSCLEROSIS IN SLOVENIAN
PATIENTS WITH TYPE 2 DIABETES MELLITUS
Merlo S1, Novák J2,3,4, Tkáčová N2, Nikolajević Starčević J5, Šantl Letonja M6, Makuc J7,
Cokan Vujkovac A7, Letonja J5, Bregar D5, Zorc M5, Rojko M5, Mankoč S5, Kruzliak P8, Petrovič D5
*Corresponding Author: Professor Daniel Petrovič, M.D., Ph.D., Institute of Histology and Embryology, Faculty
of Medicine University Ljubljana, Korytkova 2, SI-1000 Ljubljana, Slovenia. Tel: +386-1-543-7367. Fax: +386-1-
543-7361. E-mail: daniel.petrovic@mf.uni-lj.si
page: 37
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Abstract
The current study was designed to reveal possible
associations between the angiotensin-converting-
enzyme (ACE) gene polymorphisms (rs4646994
and rs4341) with markers of carotid atherosclerosis
in patients with type 2 diabetes mellitus (T2DM) in a
4-year-long follow-up study. Five hundred and ninety-
five T2DM subjects and 200 control subjects were
enrolled. Genotyping of ACE polymorphisms was
performed using KASPar assays, and ultrasound examinations
were performed twice (at the enrollment
and at follow-up). With regard to the progression
of atherosclerosis in subjects with T2DM, statistically
significant differences were demonstrated in the
change of the sum of carotid plaques thickness for the
rs4646994 polymorphism. We did not demonstrate
an association between the tested polymorphisms
(rs4646994 and rs4341) and either carotid intima
media thickness (CIMT) or CIMT progression in a
3.8-year period. In our study, we demonstrated that
subjects with T2DM with the DD genotype of the
rs4646994 [ACE insertion/deletion (I/D)] polymorphism
had faster progression of atherosclerosis in
comparison to subjects with other genotypes.
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