ADULT B LYMPHOBLASTIC LEUKEMIA WITH A
NOVEL DE NOVO CHROMOSOMAL TRANSLOCATION
[der(9)t(9;12)(p24;q12),-12]: A CASE REPORT
Gadhia PK, Shastri GD, Shastri EG
*Corresponding Author: Professor Pankaj K. Gadhia, Department of Biosciences, Veer Narmad South Gujarat
University, Surat, 395009 Gujarat, India; Mobile: +91-9825163395; E-mail: genecare3@gmail.com
page: 69
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Abstract
Patients suffering from adult acute lymphoblastic
leukemia (ALL) are very ill and present most
commonly with shortness of breath during physical
activity, a pale complexion from anemia, a very low
platelet count, the appearance of pinhead-sized red
spots under the skin called petechiae, or prolonged
bleeding from minor cuts and discomfort in the
bones and joints. Fever in the absence of an obvious
cause is common. Leukemic lymphoblasts may accumulate
in the lymphatic system, and lymph nodes
can be enlarged. We report a young adult male with
a novel translocation in ALL, who had vague (uncertain)
minimal symptoms and splenomegaly.
The patient had a unique cytogenetic abnormality:
45,XY,der(9)t(9;12)(p24;q12),-12, which has not
been previously described in ALL. This is categorized
as a poor risk due to his failure to achieve
complete remission after induction chemotherapy.
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