ETHNIC VARIATION IN INTERLEUKIN-6 –174 (G/C)
POLYMORPHISM IN THE MALAYSIAN POPULATION
Gan G-G*, Subramaniam R, Lian L-H, Nadarajan VS
*Corresponding Author: Professor Dr. Gin-Gin Gan, Department of Medicine, Faculty of Medicine, University
Malaya, Lembah Pantai, Kuala Lumpur, Malaysia; Tel.: +603-79-492-429; Fax: +603-79-556-936; E-mail:
gangg@ummc.edu.my
page: 53
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Abstract
Interleukin-6 (IL-6) is one of the cytokines that
has been well studied and implicated in many diseases
including cancers. The frequency of the IL-6
–174 (G/C) polymorphism had been proven to differ
in various populations. Malaysia is a country with
three major ethnic populations, Malays, Chinese and
Indians. In this study, we proposed to determine the G
or C allele frequency of the IL-6 –174 polymorphism
in these three populations. A total of 348 blood samples
were available for analysis. The median age for
the subjects was 31 years. There were a total of 245
males and 103 females. A total of 86 Malays (25.0%),
122 Chinese (33.0%) and 140 Indians (40.0%) were
genotyped. The result showed a significant difference
in the G or C allele frequency of the –174 polymorphism.
The total frequencies for the G and C alleles
were 91.0 and 9.0%, respectively. In the Malays,
the allele frequency of the C allele was 4.0% compared
with 19.0% in the Indians. The C allele was
not detected in the Chinese population. This finding
is the first reported on the Malaysian population and
may be important in determining risk of diseases associated
with the IL-6 polymorphism in these three
populations.
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