DETECTING SEX-BIASED GENE FLOW IN AFRICANAMERICANS
THROUGH THE ANALYSIS OF INTRA- AND
INTER-POPULATION VARIATION AT MITOCHONDRIAL
DNA AND Y- CHROMOSOME MICROSATELLITES
Battaggia C1, Anagnostou P1,3, Bosch I4, Brisighelli F4, Destro-Bisol G1,3, Capocasa M2,3,*
*Corresponding Author: Dr. Marco Capocasa, Dipartimento di Biologia e Biotecnologie “Charles Darwin”, Università
“La Sapienza”, Roma, Italy, P.le A. Moro 5, 00185 Roma, Italia; Tel.: +39-6-4991-2725; Fax: ++39-6-4991-2771;
E-mail: marco.capocasa@uniroma1.it
page: 7
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Abstract
This study reports on variations at the mitochondrial
DNA (mtDNA) hypervariable region 1 (HVR-1)
and at seven Y-chromosome microsatellites in an
African-American population sample from Chicago,
IL, USA. Our results support the hypothesis that the
population studied had undergone a European malebiased
gene flow. We show that comparisons of intraand
inter-population diversity parameters between
African-Americans, Europeans and Africans may
help detect sex-biased gene flow, providing a complement
to quantitative methods to estimate genetic
admixture.
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